Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway

Figure 2

Bergenin inhibits the formation of the extracellular matrix. (a) Levels of serum HA and LN expressed as the (). (b) mRNA expression of collagen I, α-SMA, and TIMP1 assessed by real-time PCR (). (c) Protein expression of collagen I, α-SMA, and TIMP1 assessed by western blotting. The quantitative evaluation was determined by relative band density. (d) Immunohistochemical staining of α-SMA and TIMP1 (original ). for CCl₄/BDL vs. sham, ^# for CCl₄/BDL+B20 vs. CCl₄/BDL, and ^{^} for CCl₄/BDL+B40 vs. CCl₄/BDL+B20.

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