Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway

Figure 5

Mechanism of action of bergenin in liver fibrosis. The expression of PPAR-γ and RXR-α was increased, and the TGF-β pathway was inhibited following treatment with bergenin. The Smad2/3 that act downstream were not activated by phosphorylation and transported into the nucleus. Furthermore, Beclin-1 could not be bound to promote transcription, which reduced the likelihood of LC3-I to LC3-II transformation, which decreased fibrosis due to a lack of energy supply for HSC activation.