The rapidly developing multidisciplinary field of study on the interface between biology and nanotechnology has greatly expanded researchers’ perspectives into new research directions, revealed detailed information in cell signaling, provided sensitive tools to study neurological activities, and opened doors to new diagnostic and therapy methods (i.e., theranostics) that have great potentials to improve people’s health. The biological related surfaces or interfaces include a wide range of biophysical systems. For instance, living cell surfaces have shown complex components when the detection resolutions reach down to the nanometer scale. Many of these nanoscale components or structures are essential to the basic physiological functions of bacteria, plants, and human bodies. On the other hand, in the fields of biophysics and bioengineering, artificial lipid bilayers and other designed biological interfaces help researchers understand the structures and functions of biomolecules in the simplified yet quantitative models. Moreover, nanomaterials and nanoscale devices pave the way for the development of efficient drug delivery methods, smaller implanted biosensors, and more advanced brain-machine interfaces.

Under this general framework, we invite the scientific community to contribute in the form of original research articles as well as review articles dealing with the latest development of novel bioimaging or surface/interface detection methods with resolutions in the nanometer scale. Particular interest will be given to papers exploring the applications of scanning microscopies in the emerging research areas of nanobiotechnology and nanomedicine. Original, high-quality contributions that are not yet published or that are not currently under review by other journals or peer-reviewed conferences are sought.

Potential topics include but are not limited to the following:

• Use of scanning microscopies in nanomedicine
• Synthesis and surface characterizations of nanomaterials used for drug delivery
• Instrumentation of novel bioimaging approaches with nanometer resolutions
• Bioimaging methods for real-time cellular interactions and activities
• Bioimaging processing methods to improve the resolution at the nanometer scale
• High-throughput and multiplex scanning methods to detect biological activities at the nanometer scale