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Stem Cells International
Volume 2011, Article ID 570125, 10 pages
http://dx.doi.org/10.4061/2011/570125
Review Article

Preclinical Studies on Mesenchymal Stem Cell-Based Therapy for Growth Plate Cartilage Injury Repair

1School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, City East Campus, G.P.O Box 2471, Adelaide, SA 5001, Australia
2Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
3Department of Orthopaedic Surgery, Women's and Children's Hospital, North Adelaide, SA 5006, Australia

Received 15 March 2011; Accepted 7 June 2011

Academic Editor: Shinn-Chih Wu

Copyright © 2011 Rosa Chung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the last two decades, there has been a strong interest in searching for biological treatments for regeneration of injured growth plate cartilage and prevention of its bony repair. Various means have been tried, including implantation of chondrocytes, mesenchymal stem cell (MSC), together with exogenous growth factor and scaffolds, and gene therapy. However, with the lack of success with chondrocytes, more research has focussed on MSC-based treatments. In addition to circumvent limitations with MSC-based treatments (including cell harvest-associated morbidity, difficulties/time/cost involved in MSC isolation and ex vivo expansion, and potential disease transmission), mobilising endogenous MSCs to the growth plate injury site and enhancing in situ regeneration mechanisms would represent an alternative attractive approach. Further studies are required to investigate the potential particularly in large animal models or clinical setting of the ex vivo MSC approach and the feasibility of the endogenous MSC in situ approach in growth plate regeneration.