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Stem Cells International
Volume 2011, Article ID 954275, 8 pages
Review Article

Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type

Division of Biomedical Sciences, Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia

Received 4 June 2011; Revised 17 August 2011; Accepted 23 August 2011

Academic Editor: Roland Jurecic

Copyright © 2011 Helen C. O'Neill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen.