Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury
IL-10 antibody reduces the tissue sparing capacity of BMSC-CM. (a) H&E histological analysis of kidneys from cisplatin-treated rats administered either BMSC-CM plus a neutralizing IL-10 antibody (), BMSC-CM (), or saline (). Animals were sacrificed at 5 days after cisplatin for tissue harvesting. (b) Quantification of tissue injury in the outer cortex (OC), inner cortex (IC), and outer stripe of the outer medulla (OSOM) for rats treated with either BMSC-CM plus a neutralizing IL-10 antibody, BMSC-CM, or saline. Scale bar = 200 μm. by Student’s -test.
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