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Stem Cells International
Volume 2012, Article ID 652034, 4 pages
Review Article

Safety of Mesenchymal Stem Cells for Clinical Application

1State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
2Department of Hematology, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450052, China

Received 18 February 2012; Accepted 13 March 2012

Academic Editor: Selim Kuçi

Copyright © 2012 Youwei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.