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Stem Cells International
Volume 2015, Article ID 484528, 10 pages
http://dx.doi.org/10.1155/2015/484528
Research Article

All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study

1Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
2Center for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

Received 8 January 2015; Revised 11 March 2015; Accepted 11 March 2015

Academic Editor: Antonio Salgado

Copyright © 2015 Deng Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary materials contains:

Supplementary Figure 1: Cytokine secretion measured by CBA under different circumstances. MSCs secreted only IL-6 but barely other cytokines. In the co-culture of MSCs and PBMCs, the production of IL-6 and IFN-γ was significantly high, especially IL-6. These seven bands stood for seven different cytokines within the detecting spectrum of the CBA kit. The fluorescence intensities were positively related to cytokine concentrations.

  1. Supplementary Material