Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016, Article ID 2683042, 10 pages
http://dx.doi.org/10.1155/2016/2683042
Research Article

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs

1Department of Molecular Medicine and Experimental Medicine, Sapienza University, 00161 Rome, Italy
2Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy
3Santa Lucia IRCCS Foundation, 00143 Rome, Italy
4Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio of Chieti-Pescara, 66013 Chieti, Italy
5Mawson Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
6Department of Experimental Medicine and Surgery, University of Rome “Tor Vergata”, 00133 Rome, Italy
7Center for Life NanoScience at Sapienza, Italian Institute of Technology, Viale Regina Elena 291, 00161 Rome, Italy
8Department of Hematology/Oncology and Stem Cell Transplantation, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
9Department of Neuroscience and Neurorehabilitation, Neurosurgery Unit, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
10Department of Pediatric Science, University of Pavia, 27100 Pavia, Italy

Received 24 July 2015; Accepted 2 December 2015

Academic Editor: Maria C. Rangel

Copyright © 2016 Giuseppina Catanzaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Mastronuzzi, E. Miele, A. Po et al., “Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features,” BMC Cancer, vol. 14, no. 1, article 262, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. Vanner, M. Remke, M. Gallo et al., “Quiescent Sox2+ cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma,” Cancer Cell, vol. 26, no. 1, pp. 33–47, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Po, E. Ferretti, E. Miele et al., “Hedgehog controls neural stem cells through p53-independent regulation of Nanog,” The EMBO Journal, vol. 29, no. 15, pp. 2646–2658, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. S. K. Singh, C. Hawkins, I. D. Clarke et al., “Identification of human brain tumour initiating cells,” Nature, vol. 432, no. 7015, pp. 396–401, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. X. Wu, P. A. Northcott, A. Dubuc et al., “Clonal selection drives genetic divergence of metastatic medulloblastoma,” Nature, vol. 482, no. 7386, pp. 529–533, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. M.-T. Mueller, P. C. Hermann, J. Witthauer et al., “Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer,” Gastroenterology, vol. 137, no. 3, pp. 1102–1113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. I. S. Florian, C. Tomuleasa, O. Soritau et al., “Cancer stem cells and malignant gliomas. From pathophysiology to targeted molecular therapy,” Journal of B.U.ON., vol. 16, no. 1, pp. 16–23, 2011. View at Google Scholar
  8. M. Ronci, G. Catanzaro, L. Pieroni et al., “Proteomic analysis of human sonic hedgehog (SHH) medulloblastoma stem-like cells,” Molecular BioSystems, vol. 11, no. 6, pp. 1603–1611, 2015. View at Publisher · View at Google Scholar
  9. Q. Li, K. Shen, Y. Zhao, C. Ma, J. Liu, and J. Ma, “MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin signaling pathway,” Journal of Translational Medicine, vol. 11, article 302, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Ferretti, E. De Smaele, A. Po et al., “MicroRNA profiling in human medulloblastoma,” International Journal of Cancer, vol. 124, no. 3, pp. 568–577, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Ferretti, E. De Smaele, E. Miele et al., “Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells,” The EMBO Journal, vol. 27, no. 19, pp. 2616–2627, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Alanazi, P. Hoffmann, D. L. Adelson, and L. Mariño-Ramírez, “MicroRNAs are part of the regulatory network that controls EGF induced apoptosis, including elements of the JAK/STAT pathway, in A431 cells,” PLoS ONE, vol. 10, no. 3, Article ID e0120337, 2015. View at Publisher · View at Google Scholar
  13. L. Di Marcotullio, E. Ferretti, A. Greco et al., “Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination,” Nature Cell Biology, vol. 8, no. 12, pp. 1415–1423, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Ferretti, L. Di Marcotullio, M. Gessi et al., “Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets,” Oncogene, vol. 25, no. 55, pp. 7267–7273, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Xu, T. Papagiannakopoulos, G. Pan, J. A. Thomson, and K. S. Kosik, “MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells,” Cell, vol. 137, no. 4, pp. 647–658, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Hui, L. Yuntao, L. Lun et al., “MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1,” PLoS ONE, vol. 8, no. 1, Article ID e54932, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Qing, G. Yingmao, B. Lujun, and L. shaoling, “Role of Npm1 in proliferation, apoptosis and differentiation of neural stem cells,” Journal of the Neurological Sciences, vol. 266, no. 1-2, pp. 131–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-P. Yang, Y. Chien, G.-Y. Chiou et al., “Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI,” Biomaterials, vol. 33, no. 5, pp. 1462–1476, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Zanini, E. Ercole, G. Mandili et al., “Medullospheres from DAOY, UW228 and ONS-76 cells: increased stem cell population and proteomic modifications,” PLoS ONE, vol. 8, no. 5, Article ID e63748, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Resnitzky, M. Gossen, H. Bujard, and S. I. Reed, “Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system,” Molecular and Cellular Biology, vol. 14, no. 3, pp. 1669–1679, 1994. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Italiano, L. Bianchini, E. Gjernes et al., “Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas,” Clinical Cancer Research, vol. 15, no. 18, pp. 5696–5703, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. J. Molenaar, M. E. Ebus, J. Koster et al., “Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma,” Cancer Research, vol. 68, no. 8, pp. 2599–2609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Akli and K. Keyomarsi, “Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy,” Cancer Biology & Therapy, vol. 2, no. 4, pp. S38–S47, 2003. View at Google Scholar · View at Scopus
  24. P. C. Sanchez-Diaz, T.-H. Hsiao, J. C. Chang et al., “De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development,” PLoS ONE, vol. 8, no. 4, Article ID e61622, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. P. A. Northcott, A. Fernandez-L, J. P. Hagan et al., “The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors,” Cancer Research, vol. 69, no. 8, pp. 3249–3255, 2009. View at Publisher · View at Google Scholar
  26. X. M. Xu, J. C. Qian, Z. L. Deng et al., “Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer,” Oncology Letters, vol. 4, no. 2, pp. 339–345, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. R. R. Lulla, F. F. Costa, J. M. Bischof et al., “Identification of differentially expressed MicroRNAs in osteosarcoma,” Sarcoma, vol. 2011, Article ID 732690, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. F. F. Costa, J. M. Bischof, E. F. Vanin et al., “Identification of micrornas as potential prognostic markers in ependymoma,” PLoS ONE, vol. 6, no. 10, Article ID e25114, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Liu, W. Guo, J. Shi et al., “MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma,” Journal of Hepatology, vol. 56, no. 2, pp. 389–396, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Arigoni, G. Barutello, F. Riccardo et al., “MiR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2,” The American Journal of Pathology, vol. 182, no. 6, pp. 2058–2070, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Aranda-Orgillés, A. Trockenbacher, J. Winter et al., “The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex,” Human Genetics, vol. 123, no. 2, pp. 163–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. M. K. Farrugia, S. B. Sharma, C. Lin et al., “Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer,” Cell Death & Disease, vol. 6, no. 3, Article ID e1699, 2015. View at Publisher · View at Google Scholar
  33. J. Ma, Y. Yao, P. Wang et al., “MiR-152 functions as a tumor suppressor in glioblastoma stem cells by targeting Krüppel-like factor 4,” Cancer Letters, vol. 355, no. 1, pp. 85–95, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. X. Dolcet, D. Llobet, J. Pallares, and X. Matias-Guiu, “NF-κB in development and progression of human cancer,” Virchows Archiv, vol. 446, no. 5, pp. 475–482, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. M. W. Feinberg, Z. Cao, A. K. Wara, M. A. Lebedeva, S. SenBanerjee, and M. K. Jain, “Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages,” Journal of Biological Chemistry, vol. 280, no. 46, pp. 38247–38258, 2005. View at Publisher · View at Google Scholar · View at Scopus