Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016, Article ID 4328362, 8 pages
http://dx.doi.org/10.1155/2016/4328362
Review Article

Inhibition of Myocardial Ischemia/Reperfusion Injury by Exosomes Secreted from Mesenchymal Stem Cells

Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai 200032, China

Received 24 January 2016; Accepted 29 March 2016

Academic Editor: Yaoliang Tang

Copyright © 2016 Heng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. E. Hatzistergos, H. Quevedo, B. N. Oskouei et al., “Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation,” Circulation Research, vol. 107, no. 7, pp. 913–922, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Menasché, A. A. Hagège, J.-T. Vilquin et al., “Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction,” Journal of the American College of Cardiology, vol. 41, no. 7, pp. 1078–1083, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. E. C. Perin, H. F. R. Dohmann, R. Borojevic et al., “Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure,” Circulation, vol. 107, no. 18, pp. 2294–2302, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Tolar, A. J. Nauta, M. J. Osborn et al., “Sarcoma derived from cultured mesenchymal stem cells,” STEM CELLS, vol. 25, no. 2, pp. 371–379, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Gnecchi, Z. Zhang, A. Ni, and V. J. Dzau, “Paracrine mechanisms in adult stem cell signaling and therapy,” Circulation Research, vol. 103, no. 11, pp. 1204–1219, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. J.-A. Cho, Y.-S. Lee, S.-H. Kim, J.-K. Ko, and C.-W. Kim, “MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models,” Cancer Letters, vol. 275, no. 2, pp. 256–265, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. L. Hood, R. S. Sa, and S. A. Wickline, “Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis,” Cancer Research, vol. 71, no. 11, pp. 3792–3801, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Li, Y. Yan, B. Wang et al., “Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis,” Stem Cells and Development, vol. 22, no. 6, pp. 845–854, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Zhou, H. Xu, W. Xu et al., “Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro,” Stem Cell Research and Therapy, vol. 4, article 34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Dorronsoro and P. D. Robbins, “Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes,” Stem Cell Research & Therapy, vol. 4, no. 2, article 39, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Timmers, S. K. Lim, F. Arslan et al., “Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium,” Stem Cell Research, vol. 1, no. 2, pp. 129–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. R. C. Lai, F. Arslan, M. M. Lee et al., “Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury,” Stem Cell Research, vol. 4, no. 3, pp. 214–222, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. C. Lai, F. Arslan, S. S. Tan et al., “Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles,” Journal of Molecular and Cellular Cardiology, vol. 48, no. 6, pp. 1215–1224, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Arslan, R. C. Lai, M. B. Smeets et al., “Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury,” Stem Cell Research, vol. 10, no. 3, pp. 301–312, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Kang, R. Ma, W. Cai et al., “Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via akt signaling pathway following myocardial infarction,” Stem Cells International, vol. 2015, Article ID 659890, 14 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Yu, H. W. Kim, M. Gong et al., “Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection,” International Journal of Cardiology, vol. 182, pp. 349–360, 2015. View at Publisher · View at Google Scholar
  17. Y. Zhao, X. Sun, W. Cao et al., “Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury,” Stem Cells International, vol. 2015, Article ID 761643, 12 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Feng, W. Huang, M. Wani, X. Yu, and M. Ashraf, “Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22,” PLoS ONE, vol. 9, no. 2, Article ID e88685, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Akyurekli, Y. Le, R. B. Richardson, D. Fergusson, J. Tay, and D. S. Allan, “A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles,” Stem Cell Reviews and Reports, vol. 11, no. 1, pp. 150–160, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. R. M. Johnstone, “The Jeanne Manery-Fisher Memorial Lecture 1991. Maturation of reticulocytes: formation of exosomes as a mechanism for shedding membrane proteins,” Biochemistry and Cell Biology, vol. 70, no. 3-4, pp. 179–190, 1992. View at Google Scholar
  21. J. Ratajczak, M. Wysoczynski, F. Hayek, A. Janowska-Wieczorek, and M. Z. Ratajczak, “Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication,” Leukemia, vol. 20, no. 9, pp. 1487–1495, 2006. View at Publisher · View at Google Scholar · View at Scopus