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Stem Cells International
Volume 2016, Article ID 4717184, 10 pages
http://dx.doi.org/10.1155/2016/4717184
Review Article

Cell-Based Strategies for Meniscus Tissue Engineering

1Beijing Key Laboratory of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, Institute of Orthopaedics, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China
2First Hospital of Shanxi Medical University, Shanxi Medical University, No. 65, Jiefang Nan Road, Yingze District, Taiyuan 030012, China
3Institute of Orthopedics, First Hospital of Shanxi Medical University, No. 85, Jiefang Nan Road, Yingze District, Taiyuan 030012, China

Received 7 December 2015; Revised 6 February 2016; Accepted 11 February 2016

Academic Editor: Fang Yang

Copyright © 2016 Wei Niu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. E. Baker, A. C. Peckham, F. Pupparo, and J. C. Sanborn, “Review of meniscal injury and associated sports,” The American Journal of Sports Medicine, vol. 13, no. 1, pp. 1–4, 1985. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Perrone, “Upon a case of right internal meniscus injur, meniscectomy,” Medicina, Cirurgia, Farmacia, vol. 8, pp. 20–23, 1946. View at Google Scholar
  3. M. Pazzi, “Indications for partial meniscectomy,” Rivista Degli Infortuni e Delle Malattie Professionali, vol. 46, pp. 691–700, 1959. View at Google Scholar · View at Scopus
  4. W. A. Grana, S. Connor, and S. Hollingsworth, “Partial arthroscopic meniscectomy: a preliminary report,” Clinical Orthopaedics and Related Research, vol. 164, pp. 78–83, 1982. View at Google Scholar · View at Scopus
  5. J. C. Garrett and R. N. Stevensen, “Meniscal transplantation in the human knee: a preliminary report,” Arthroscopy, vol. 7, no. 1, pp. 57–62, 1991. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Liu, I. C. Toma, M. Mastrogiacomo, C. Krettek, G. Von Lewinski, and M. Jagodzinski, “Meniscus reconstruction: today's achievements and premises for the future,” Archives of Orthopaedic and Trauma Surgery, vol. 133, no. 1, pp. 95–109, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. C. R. Clark and J. A. Ogden, “Development of the menisci of the human knee joint. Morphological changes and their potential role in childhood meniscal injury,” The Journal of Bone & Joint Surgery—American Volume, vol. 65, no. 4, pp. 538–547, 1983. View at Google Scholar · View at Scopus
  8. S. P. Arnoczky and R. F. Warren, “Microvasculature of the human meniscus,” The American Journal of Sports Medicine, vol. 10, no. 2, pp. 90–95, 1982. View at Publisher · View at Google Scholar · View at Scopus
  9. B. B. Seedhom, D. Dowson, and V. Wright, “Proceedings: functions of the menisci. A preliminary study,” Annals of the Rheumatic Diseases, vol. 33, article 111, 1974. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Jaspers, A. de Lange, R. Huiskes, and T. J. van Rens, “The mechanical function of the meniscus, experiments on cadaveric pig knee-joints,” Acta Orthopædica Belgica, vol. 46, pp. 663–668, 1980. View at Google Scholar
  11. P. Renström and R. J. Johnson, “Anatomy and biomechanics of the menisci,” Clinics in Sports Medicine, vol. 9, no. 3, pp. 523–538, 1990. View at Google Scholar · View at Scopus
  12. M. L. Zimny, D. J. Albright, and E. Dabezies, “Mechanoreceptors in the human medial meniscus,” Acta Anatomica, vol. 133, no. 1, pp. 35–40, 1988. View at Publisher · View at Google Scholar · View at Scopus
  13. K. L. Markolf, J. S. Mensch, and H. C. Amstutz, “Stiffness and laxity of the knee—the contributions of the supporting structures. A quantitative in vitro study,” The Journal of Bone & Joint Surgery—American Volume, vol. 58, no. 5, pp. 583–594, 1976. View at Google Scholar · View at Scopus
  14. P. Ficat, “Role of the meniscus in traumatology of the knee,” Toulouse Médical, vol. 54, no. 3, pp. 147–156, 1953. View at Google Scholar · View at Scopus
  15. J. Quintero Esguerra and V. Malagon Castro, “Traumatic lesions of the meniscus of the knee,” Medicina y Cirugía, vol. 16, no. 5, pp. 181–187, 1952. View at Google Scholar · View at Scopus
  16. U. M. Kujala, M. Kvist, and K. Osterman, “Knee injuries in athletes. Review of exertion injuries and retrospective study of outpatient sports clinic material,” Sports Medicine, vol. 3, no. 6, pp. 447–460, 1986. View at Publisher · View at Google Scholar · View at Scopus
  17. K. E. DeHaven, “Meniscus repair in the athlete,” Clinical Orthopaedics and Related Research, vol. 198, pp. 31–35, 1985. View at Google Scholar · View at Scopus
  18. C. L. Cox, J. P. Deangelis, R. A. Magnussen, R. W. Fitch, and K. P. Spindler, “Meniscal tears in athletes,” Journal of Surgical Orthopaedic Advances, vol. 18, no. 1, pp. 2–8, 2009. View at Google Scholar · View at Scopus
  19. M. E. Baratz, F. H. Fu, and R. Mengato, “Meniscal tears: The effect of meniscectomy and of repair on intraarticular contact areas and stress in the human knee. A preliminary report,” The American Journal of Sports Medicine, vol. 14, no. 4, pp. 270–275, 1986. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Horsky, E. Huraj Sr., E. Huraj Jr., and A. Sklovsky, “Degenerative changes in the knee joint after meniscectomy,” Acta Chirurgiae orthopaedicae et Traumatologiae Čechoslovaca, vol. 54, pp. 517–521, 1987. View at Google Scholar
  21. I. P. Pengas, A. Assiotis, W. Nash, J. Hatcher, J. Banks, and M. J. McNicholas, “Total meniscectomy in adolescents: a 40-year follow-up,” The Journal of Bone and Joint Surgery—British Volume, vol. 94, no. 12, pp. 1649–1654, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. J. Salata, A. E. Gibbs, and J. K. Sekiya, “A systematic review of clinical outcomes in patients undergoing meniscectomy,” The American Journal of Sports Medicine, vol. 38, no. 9, pp. 1907–1916, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. M. D. Northmore-Ball, D. J. Dandy, and R. W. Jackson, “Arthroscopic, open partial, and total meniscectomy. A comparative study,” The Journal of Bone & Joint Surgery—British Volume, vol. 65, no. 4, pp. 400–404, 1983. View at Google Scholar · View at Scopus
  24. K. E. DeHaven, “Meniscus repair—open vs. Arthroscopic,” Arthroscopy, vol. 1, pp. 173–174, 1985. View at Google Scholar
  25. F. Steenbrugge, R. Verdonk, and K. Verstraete, “Long-term assessment of arthroscopic meniscus repair: a 13-year follow-up study,” The Knee, vol. 9, no. 3, pp. 181–187, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Majewski, R. Stoll, W. Müller, and N. F. Friederich, “Rotatory stability of the knee after arthroscopic meniscus suture repair: a 5-to-17-year follow-up study of isolated medial and lateral meniscus tears,” Acta Orthopaedica Belgica, vol. 75, no. 3, pp. 354–359, 2009. View at Google Scholar · View at Scopus
  27. F. Steenbrugge, J. Corteel, R. Verdonk, and K. Verstraete, “Long-term assessment of arthroscopic meniscus repair,” Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur, vol. 89, no. 8, pp. 699–706, 2003. View at Google Scholar · View at Scopus
  28. J. R. Giuliani, T. C. Burns, S. J. Svoboda, K. L. Cameron, and B. D. Owens, “Treatment of meniscal injuries in young athletes,” The Journal of Knee Surgery, vol. 24, no. 2, pp. 93–100, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. N. A. Smith, N. MacKay, M. Costa, and T. Spalding, “Meniscal allograft transplantation in a symptomatic meniscal deficient knee: a systematic review,” Knee Surgery, Sports Traumatology, Arthroscopy, vol. 23, no. 1, pp. 270–279, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. B. Vundelinckx, J. Vanlauwe, and J. Bellemans, “Long-term subjective, clinical, and radiographic outcome evaluation of meniscal allograft transplantation in the knee,” The American Journal of Sports Medicine, vol. 42, no. 7, pp. 1592–1599, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Scotti, M. T. Hirschmann, P. Antinolfi, I. Martin, and G. M. Peretti, “Meniscus repair and regeneration: review on current methods and research potential,” European Cells & Materials, vol. 26, pp. 150–170, 2013. View at Google Scholar · View at Scopus
  32. S.-W. Kang, S.-M. Son, J.-S. Lee et al., “Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model,” Journal of Biomedical Materials Research—Part A, vol. 78, no. 3, pp. 659–671, 2006. View at Google Scholar · View at Scopus
  33. B. B. Mandal, S.-H. Park, E. S. Gil, and D. L. Kaplan, “Multilayered silk scaffolds for meniscus tissue engineering,” Biomaterials, vol. 32, no. 2, pp. 639–651, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. M. B. Pabbruwe, W. Kafienah, J. F. Tarlton, S. Mistry, D. J. Fox, and A. P. Hollander, “Repair of meniscal cartilage white zone tears using a stem cell/collagen-scaffold implant,” Biomaterials, vol. 31, no. 9, pp. 2583–2591, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. J. J. Warnock, J. Spina, G. Bobe et al., “Culture of canine synoviocytes on porcine intestinal submucosa scaffolds as a strategy for meniscal tissue engineering for treatment of meniscal injury in dogs,” Veterinary Journal, vol. 199, no. 1, pp. 49–56, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. C. J. Walsh, D. Goodman, A. I. Caplan, and V. M. Goldberg, “Meniscus regeneration in a rabbit partial meniscectomy model,” Tissue Engineering, vol. 5, no. 4, pp. 327–337, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. C. H. Lee, S. A. Rodeo, L. A. Fortier, C. Lu, C. Erisken, and J. J. Mao, “Protein-releasing polymeric scaffolds induce fibrochondrocytic differentiation of endogenous cells for knee meniscus regeneration in sheep,” Science Translational Medicine, vol. 6, no. 266, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. K. R. Stone, W. G. Rodkey, R. Webber, L. McKinney, and J. R. Steadman, “Meniscal regeneration with copolymeric collagen scaffolds. In vitro and in vivo studies evaluated clinically, histologically, and biochemically,” The American Journal of Sports Medicine, vol. 20, no. 2, pp. 104–111, 1992. View at Publisher · View at Google Scholar · View at Scopus
  39. K. R. Stone, J. R. Steadman, W. G. Rodkey, and S.-T. Li, “Regeneration of meniscal cartilage with use of a collagen scaffold. Analysis of preliminary data,” The Journal of Bone & Joint Surgery—American Volume, vol. 79, no. 12, pp. 1770–1777, 1997. View at Google Scholar · View at Scopus
  40. N. J. Gunja, R. K. Uthamanthil, and K. A. Athanasiou, “Effects of TGF-β1 and hydrostatic pressure on meniscus cell-seeded scaffolds,” Biomaterials, vol. 30, no. 4, pp. 565–573, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. N. J. Gunja and K. A. Athanasiou, “Additive and synergistic effects of bFGF and hypoxia on leporine meniscus cell-seeded PLLA scaffolds,” Journal of Tissue Engineering and Regenerative Medicine, vol. 4, no. 2, pp. 115–122, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. U. Freymann, M. Endres, U. Goldmann, M. Sittinger, and C. Kaps, “Toward scaffold-based meniscus repair: effect of human serum, hyaluronic acid and TGF-ß3 on cell recruitment and re-differentiation,” Osteoarthritis and Cartilage, vol. 21, no. 5, pp. 773–781, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. N. L. Nerurkar, W. Han, R. L. Mauck, and D. M. Elliott, “Homologous structure-function relationships between native fibrocartilage and tissue engineered from MSC-seeded nanofibrous scaffolds,” Biomaterials, vol. 32, no. 2, pp. 461–468, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. B. M. Baker, R. P. Shah, A. H. Huang, and R. L. Mauck, “Dynamic tensile loading improves the functional properties of mesenchymal stem cell-laden nanofiber-based fibrocartilage,” Tissue Engineering—Part A, vol. 17, no. 9-10, pp. 1445–1455, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Okuno, T. Muneta, H. Koga et al., “Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model,” Journal of Orthopaedic Research, vol. 32, no. 7, pp. 928–936, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. G.-K. Tan, D. L. M. Dinnes, P. T. Myers, and J. J. Cooper-White, “Effects of biomimetic surfaces and oxygen tension on redifferentiation of passaged human fibrochondrocytes in 2D and 3D cultures,” Biomaterials, vol. 32, no. 24, pp. 5600–5614, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. A. B. Adesida, A. Mulet-Sierra, L. Laouar, and N. M. Jomha, “Oxygen tension is a determinant of the matrix-forming phenotype of cultured human meniscal fibrochondrocytes,” PLoS ONE, vol. 7, no. 6, Article ID e39339, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Petri, K. Ufer, I. Toma et al., “Effects of perfusion and cyclic compression on in vitro tissue engineered meniscus implants,” Knee Surgery, Sports Traumatology, Arthroscopy, vol. 20, no. 2, pp. 223–231, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. L. A. Setton, F. Guilak, E. W. Hsu, and T. P. Vail, “Biomechanical factors in tissue engineered meniscal repair,” Clinical Orthopaedics and Related Research, no. 367, supplement, pp. S254–S272, 1999. View at Google Scholar
  50. A. C. Aufderheide and K. A. Athanasiou, “Comparison of scaffolds and culture conditions for tissue engineering of the knee meniscus,” Tissue Engineering, vol. 11, no. 7-8, pp. 1095–1104, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. B. Haddad, A. H. Pakravan, S. Konan, A. Adesida, and W. Khan, “A systematic review of tissue engineered meniscus: cell-based preclinical models,” Current Stem Cell Research & Therapy, vol. 8, no. 3, pp. 222–231, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. C. A. McDevitt and R. J. Webber, “The ultrastructure and biochemistry of meniscal cartilage,” Clinical Orthopaedics and Related Research, no. 252, pp. 8–18, 1990. View at Google Scholar · View at Scopus
  53. H. S. Cheung, “Distribution of type I, II, III and v in the pepsin solubilized collagens in bovine menisci,” Connective Tissue Research, vol. 16, no. 4, pp. 343–356, 1987. View at Publisher · View at Google Scholar · View at Scopus
  54. K. Nakata, K. Shino, M. Hamada et al., “Human meniscus cell: characterization of the primary culture and use for tissue engineering,” Clinical Orthopaedics and Related Research, no. 391, supplement, pp. S208–S218, 2001. View at Google Scholar · View at Scopus
  55. P. C. M. Verdonk, R. G. Forsyth, J. Wang et al., “Characterisation of human knee meniscus cell phenotype,” Osteoarthritis and Cartilage, vol. 13, no. 7, pp. 548–560, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. G. M. Peretti, T. J. Gill, J.-W. Xu, M. A. Randolph, K. R. Morse, and D. J. Zaleske, “Cell-based therapy for meniscal repair: a large animal study,” American Journal of Sports Medicine, vol. 32, no. 1, pp. 146–158, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. V. Martinek, P. Ueblacker, K. Bräun et al., “Second generation of meniscus transplantation: in-vivo study with tissue engineered meniscus replacement,” Archives of Orthopaedic and Trauma Surgery, vol. 126, no. 4, pp. 228–234, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. B. M. Baker, A. S. Nathan, G. R. Huffman, and R. L. Mauck, “Tissue engineering with meniscus cells derived from surgical debris,” Osteoarthritis and Cartilage, vol. 17, no. 3, pp. 336–345, 2009. View at Publisher · View at Google Scholar · View at Scopus
  59. N. J. Gunja and K. A. Athanasiou, “Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes,” Arthritis Research & Therapy, vol. 9, article R93, 2007. View at Publisher · View at Google Scholar · View at Scopus
  60. A. B. Adesida, L. M. Grady, W. S. Khan, and T. E. Hardingham, “The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia,” Arthritis Research & Therapy, vol. 8, article R61, 2006. View at Publisher · View at Google Scholar · View at Scopus
  61. A. B. Adesida, L. M. Grady, W. S. Khan, S. J. Millward-Sadler, D. M. Salter, and T. E. Hardingham, “Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture,” Arthritis Research & Therapy, vol. 9, article R69, 2007. View at Publisher · View at Google Scholar · View at Scopus
  62. A. R. Esposito, M. Moda, S. M. Cattani et al., “PLDLA/PCL-T scaffold for meniscus tissue engineering,” BioResearch Open Access, vol. 2, no. 2, pp. 138–147, 2013. View at Publisher · View at Google Scholar
  63. J. J. Yoo, D. A. Bichara, X. Zhao, M. A. Randolph, and T. J. Gill, “Implant-assisted meniscal repair in vivo using a chondrocyte-seeded flexible PLGA scaffold,” Journal of Biomedical Materials Research Part: A, vol. 99, no. 1, pp. 102–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Kon, C. Chiari, M. Marcacci et al., “Tissue engineering for total meniscal substitution: animal study in sheep model,” Tissue Engineering—Part A, vol. 14, no. 6, pp. 1067–1080, 2008. View at Publisher · View at Google Scholar · View at Scopus
  65. E. Kon, G. Filardo, M. Tschon et al., “Tissue engineering for total meniscal substitution: animal study in sheep model—results at 12 months,” Tissue Engineering Part A, vol. 18, no. 15-16, pp. 1573–1582, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. C. Weinand, G. M. Peretti, S. B. Adams Jr., L. J. Bonassar, M. A. Randolph, and T. J. Gill, “An allogenic cell-based implant for meniscal lesions,” The American Journal of Sports Medicine, vol. 34, no. 11, pp. 1779–1789, 2006. View at Publisher · View at Google Scholar · View at Scopus
  67. B. J. E. de Lange-Brokaar, A. Ioan-Facsinay, G. J. V. M. van Osch et al., “Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review,” Osteoarthritis and Cartilage, vol. 20, no. 12, pp. 1484–1499, 2012. View at Publisher · View at Google Scholar · View at Scopus
  68. J. J. Warnock, D. B. Fox, A. M. Stoker, and J. L. Cook, “Evaluation of in vitro growth factor treatments on fibrochondrogenesis by synovial membrane cells from osteoarthritic and nonosteoarthritic joints of dogs,” American Journal of Veterinary Research, vol. 72, no. 4, pp. 500–511, 2011. View at Publisher · View at Google Scholar
  69. J. Spina, J. Warnock, K. Duesterdieck-Zellmer, W. Baltzer, J. Ott, and B. Bay, “Comparison of growth factor treatments on the fibrochondrogenic potential of canine fibroblast-like synoviocytes for meniscal tissue engineering,” Veterinary Surgery, vol. 43, no. 6, pp. 750–760, 2014. View at Publisher · View at Google Scholar · View at Scopus
  70. D. B. Fox, J. J. Warnock, A. M. Stoker, J. K. Luther, and M. Cockrell, “Effects of growth factors on equine synovial fibroblasts seeded on synthetic scaffolds for avascular meniscal tissue engineering,” Research in Veterinary Science, vol. 88, no. 2, pp. 326–332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  71. J. J. Warnock, D. B. Fox, A. M. Stoker et al., “Culture of equine fibroblast-like synoviocytes on synthetic tissue scaffolds towards meniscal tissue engineering: a preliminary cell-seeding study,” PeerJ, vol. 2, article e353, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. J. J. Warnock, G. Bobe, and K. F. Duesterdieck-Zellmer, “Fibrochondrogenic potential of synoviocytes from osteoarthritic and normal joints cultured as tensioned bioscaffolds for meniscal tissue engineering in dogs,” PeerJ, vol. 2, article e581, 2014. View at Publisher · View at Google Scholar
  73. E. M. Horwitz, “Stem cell plasticity: the growing potential of cellular therapy,” Archives of Medical Research, vol. 34, no. 6, pp. 600–606, 2003. View at Publisher · View at Google Scholar · View at Scopus
  74. J. Ringe, C. Kaps, G.-R. Burmester, and M. Sittinger, “Stem cells for regenerative medicine: advances in the engineering of tissues and organs,” Die Naturwissenschaften, vol. 89, no. 8, pp. 338–351, 2002. View at Publisher · View at Google Scholar · View at Scopus
  75. D. J. Schaefer, C. Klemt, X. H. Zhang, and G. B. Stark, “Tissue engineering with mesenchymal stem cells for cartilage and bone regeneration,” Der Chirurg, vol. 71, pp. 1001–1008, 2000. View at Google Scholar
  76. B. M. Baker and R. L. Mauck, “The effect of nanofiber alignment on the maturation of engineered meniscus constructs,” Biomaterials, vol. 28, no. 11, pp. 1967–1977, 2007. View at Publisher · View at Google Scholar · View at Scopus
  77. T. Yamasaki, M. Deie, R. Shinomiya et al., “Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow,” Journal of Biomedical Materials Research Part A, vol. 75, no. 1, pp. 23–30, 2005. View at Publisher · View at Google Scholar · View at Scopus
  78. N. L. Nerurkar, S. Sen, B. M. Baker, D. M. Elliott, and R. L. Mauck, “Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds,” Acta Biomaterialia, vol. 7, no. 2, pp. 485–491, 2011. View at Publisher · View at Google Scholar · View at Scopus
  79. C. De Bari, F. Dell'Accio, P. Tylzanowski, and F. P. Luyten, “Multipotent mesenchymal stem cells from adult human synovial membrane,” Arthritis and Rheumatism, vol. 44, no. 8, pp. 1928–1942, 2001. View at Publisher · View at Google Scholar · View at Scopus
  80. S. Shirasawa, I. Sekiya, Y. Sakaguchi, K. Yagishita, S. Ichinose, and T. Muneta, “In vitro chondrogenesis of human synovium-derived mesenchymal stem cells: optimal condition and comparison with bone marrow-derived cells,” Journal of Cellular Biochemistry, vol. 97, no. 1, pp. 84–97, 2006. View at Publisher · View at Google Scholar · View at Scopus
  81. K. Sakimura, T. Matsumoto, C. Miyamoto, M. Osaki, and H. Shindo, “Effects of insulin-like growth factor I on transforming growth factor β1 induced chondrogenesis of synovium-derived mesenchymal stem cells cultured in a polyglycolic acid scaffold,” Cells Tissues Organs, vol. 183, no. 2, pp. 55–61, 2006. View at Publisher · View at Google Scholar · View at Scopus
  82. D. Hatsushika, T. Muneta, T. Nakamura et al., “Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model,” Osteoarthritis and Cartilage, vol. 22, no. 7, pp. 941–950, 2014. View at Publisher · View at Google Scholar · View at Scopus
  83. D. Hatsushika, T. Muneta, M. Horie, H. Koga, K. Tsuji, and I. Sekiya, “Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model,” Journal of Orthopaedic Research, vol. 31, no. 9, pp. 1354–1359, 2013. View at Publisher · View at Google Scholar · View at Scopus
  84. M. Horie, I. Sekiya, T. Muneta et al., “Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect,” STEM CELLS, vol. 27, no. 4, pp. 878–887, 2009. View at Publisher · View at Google Scholar · View at Scopus
  85. C. T. Vangsness Jr., J. Farr II, J. Boyd, D. T. Dellaero, C. R. Mills, and M. LeRoux-Williams, “Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a Randomized, Double-Blind, Controlled Study,” The Journal of Bone & Joint Surgery—American Volume, vol. 96, no. 2, pp. 90–98, 2014. View at Publisher · View at Google Scholar · View at Scopus
  86. J. Hendriks, J. Riesle, and C. A. van Blitterswijk, “Co-culture in cartilage tissue engineering,” Journal of Tissue Engineering and Regenerative Medicine, vol. 1, no. 3, pp. 170–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  87. N. J. Gunja and K. A. Athanasiou, “Effects of co-cultures of meniscus cells and articular chondrocytes on PLLA scaffolds,” Biotechnology and Bioengineering, vol. 103, no. 4, pp. 808–816, 2009. View at Publisher · View at Google Scholar · View at Scopus
  88. S. Boeuf and W. Richter, “Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors,” Stem Cell Research & Therapy, vol. 1, article 31, 2010. View at Publisher · View at Google Scholar · View at Scopus
  89. L. Wu, J. C. H. Leijten, N. Georgi, J. N. Post, C. A. Van Blitterswijk, and M. Karperien, “Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation,” Tissue Engineering Part A, vol. 17, no. 9-10, pp. 1425–1436, 2011. View at Publisher · View at Google Scholar · View at Scopus
  90. L. Wu, H.-J. Prins, M. N. Helder, C. A. van Blitterswijk, and M. Karperien, “Trophic effects of mesenchymal stem cells in chondrocyte Co-Cultures are independent of culture conditions and cell sources,” Tissue Engineering Part: A, vol. 18, no. 15-16, pp. 1542–1551, 2012. View at Publisher · View at Google Scholar · View at Scopus
  91. H. J. Diao, C. W. Yeung, C. H. Yan, G. C. Chan, and B. P. Chan, “Bidirectional and mutually beneficial interactions between human mesenchymal stem cells and osteoarthritic chondrocytes in micromass co-cultures,” Regenerative Medicine, vol. 8, no. 3, pp. 257–269, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. X. Cui, A. Hasegawa, M. Lotz, and D. D'Lima, “Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy,” Biotechnology and Bioengineering, vol. 109, no. 9, pp. 2369–2380, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. N.-F. Matthies, A. Mulet-Sierra, N. M. Jomha, and A. B. Adesida, “Matrix formation is enhanced in co-cultures of human meniscus cells with bone marrow stromal cells,” Journal of Tissue Engineering and Regenerative Medicine, vol. 7, no. 12, pp. 965–973, 2013. View at Publisher · View at Google Scholar · View at Scopus
  94. A. Chowdhury, L. W. Bezuidenhout, A. Mulet-Sierra, N. M. Jomha, and A. B. Adesida, “Effect of interleukin-1β treatment on co-cultures of human meniscus cells and bone marrow mesenchymal stromal cells,” BMC Musculoskeletal Disorders, vol. 14, article 216, 2013. View at Publisher · View at Google Scholar · View at Scopus
  95. Y. Tan, Y. Zhang, and M. Pei, “Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa-a pilot study to engineer meniscus tissue constructs,” Tissue Engineering—Part A, vol. 16, no. 1, pp. 67–79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  96. J.-S. Ryu, Y.-H. Jung, M.-Y. Cho et al., “Co-culture with human synovium-derived mesenchymal stem cells inhibits inflammatory activity and increases cell proliferation of sodium nitroprusside-stimulated chondrocytes,” Biochemical and Biophysical Research Communications, vol. 447, no. 4, pp. 715–720, 2014. View at Publisher · View at Google Scholar · View at Scopus
  97. M. M. Higashioka, J. A. Chen, J. C. Hu, and K. A. Athanasiou, “Building an anisotropic meniscus with zonal variations,” Tissue Engineering—Part A, vol. 20, no. 1-2, pp. 294–302, 2014. View at Publisher · View at Google Scholar · View at Scopus
  98. J. M. Kelm and M. Fussenegger, “Scaffold-free cell delivery for use in regenerative medicine,” Advanced Drug Delivery Reviews, vol. 62, no. 7-8, pp. 753–764, 2010. View at Publisher · View at Google Scholar · View at Scopus
  99. B. Demirbag, P. Y. Huri, G. T. Kose, A. Buyuksungur, and V. Hasirci, “Advanced cell therapies with and without scaffolds,” Biotechnology Journal, vol. 6, no. 12, pp. 1437–1453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  100. G. A. Ballard, J. J. Warnock, G. Bobe et al., “Comparison of meniscal fibrochondrocyte and synoviocyte bioscaffolds toward meniscal tissue engineering in the dog,” Research in Veterinary Science, vol. 97, pp. 400–408, 2014. View at Publisher · View at Google Scholar · View at Scopus
  101. J. J. Warnock, G. Bobe, K. F. Duesterdieck-Zellmer et al., “Growth factor treated tensioned synoviocyte neotissues: towards meniscal bioscaffold tissue engineering,” Veterinary Journal, vol. 200, no. 1, pp. 22–30, 2014. View at Publisher · View at Google Scholar · View at Scopus
  102. Y. Moriguchi, K. Tateishi, W. Ando et al., “Repair of meniscal lesions using a scaffold-free tissue-engineered construct derived from allogenic synovial MSCs in a miniature swine model,” Biomaterials, vol. 34, no. 9, pp. 2185–2193, 2013. View at Publisher · View at Google Scholar · View at Scopus
  103. G. M. Hoben, J. C. Hu, R. A. James, and K. A. Athanasiou, “Self-assembly of fibrochondrocytes and chondrocytes for tissue engineering of the knee meniscus,” Tissue Engineering, vol. 13, no. 5, pp. 939–946, 2007. View at Publisher · View at Google Scholar · View at Scopus
  104. D. J. Huey and K. A. Athanasiou, “Maturational growth of self-assembled, functional menisci as a result of TGF-β1 and enzymatic chondroitinase-ABC stimulation,” Biomaterials, vol. 32, no. 8, pp. 2052–2058, 2011. View at Publisher · View at Google Scholar · View at Scopus
  105. P. Hadidi and K. A. Athanasiou, “Enhancing the mechanical properties of engineered tissue through matrix remodeling via the signaling phospholipid lysophosphatidic acid,” Biochemical and Biophysical Research Communications, vol. 433, no. 1, pp. 133–138, 2013. View at Publisher · View at Google Scholar · View at Scopus
  106. P. Hadidi, T. C. Yeh, J. C. Hu, and K. A. Athanasiou, “Critical seeding density improves the properties and translatability of self-assembling anatomically shaped knee menisci,” Acta Biomaterialia, vol. 11, pp. 173–182, 2015. View at Publisher · View at Google Scholar