Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016 (2016), Article ID 6183562, 9 pages
http://dx.doi.org/10.1155/2016/6183562
Research Article

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation

1Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
2Department of Cell and Developmental Biology, Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
3Bioinformatics and High-Throughput Analysis Laboratory and High-Throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children’s Research Institute, Seattle, WA 98105, USA
4Predictive Analytics, Seattle Children’s Hospital, Seattle, WA 98105, USA
5Data-Enabled Life Sciences Alliance (DELSA), Seattle, WA 98105, USA
6Department of Biomedical Informatics & Medical Education and Pediatrics, Medical School, University of Washington, Seattle, WA 98101, USA

Received 16 March 2015; Accepted 4 May 2015

Academic Editor: Stefan Liebau

Copyright © 2016 Holger A. Russ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. A. D'Amour, A. G. Bang, S. Eliazer et al., “Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells,” Nature Biotechnology, vol. 24, no. 11, pp. 1392–1401, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Van Hoof, K. A. D'Amour, and M. S. German, “Derivation of insulin-producing cells from human embryonic stem cells,” Stem Cell Research, vol. 3, no. 2-3, pp. 73–87, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Maehr, S. Chen, M. Snitow et al., “Generation of pluripotent stem cells from patients with type 1 diabetes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 37, pp. 15768–15773, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Hua, L. Shang, H. Martinez et al., “iPSC-derived β cells model diabetes due to glucokinase deficiency,” The Journal of Clinical Investigation, vol. 123, no. 7, pp. 3146–3153, 2013. View at Publisher · View at Google Scholar
  5. L. Landsman, A. Nijagal, T. J. Whitchurch et al., “Pancreatic mesenchyme regulates epithelial organogenesis throughout development,” PLoS Biology, vol. 9, no. 9, Article ID e1001143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. B. Sneddon, M. Borowiak, and D. A. Melton, “Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme,” Nature, vol. 491, no. 7426, pp. 765–768, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. P. Verzi, M. N. Stanfel, K. A. Moses et al., “Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development,” Gastroenterology, vol. 136, no. 5, pp. 1701–1710, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Guo, L. Landsman, N. Li, and M. Hebrok, “Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs,” Diabetes, vol. 62, no. 5, pp. 1581–1592, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Wiśniewski, A. Zougman, N. Nagaraj, and M. Mann, “Universal sample preparation method for proteome analysis,” Nature Methods, vol. 6, no. 5, pp. 359–362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Kolker, R. Higdon, P. Morgan et al., “SPIRE: systematic protein investigative research environment,” Journal of Proteomics, vol. 75, no. 1, pp. 122–126, 2011. View at Google Scholar
  11. The Gene Ontology Consortium, “Gene ontology annotations and resources,” Nucleic Acids Research, vol. 41, pp. D530–D535, 2013. View at Publisher · View at Google Scholar
  12. P. Picotti and R. Aebersold, “Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions,” Nature Methods, vol. 9, no. 6, pp. 555–566, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. B. MacLean, D. M. Tomazela, N. Shulman et al., “Skyline: an open source document editor for creating and analyzing targeted proteomics experiments,” Bioinformatics, vol. 26, no. 7, Article ID btq054, pp. 966–968, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Y. Galperin and X. M. Fernández-Suárez, “The 2012 nucleic acids research database issue and the online molecular biology database collection,” Nucleic Acids Research, vol. 40, no. 1, pp. D1–D8, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Y. Lee, S. H. Lee, J. H. Park, and H. J. Han, “Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways,” Cellular and Molecular Life Sciences, vol. 66, no. 8, pp. 1467–1478, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Owczarek, D. Kiryushko, M. H. Larsen et al., “Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor,” The FASEB Journal, vol. 24, no. 4, pp. 1139–1150, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Nikolova, N. Jabs, I. Konstantinova et al., “The vascular basement membrane: a niche for insulin gene expression and β cell proliferation,” Developmental Cell, vol. 10, no. 3, pp. 397–405, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Bar, H. A. Russ, S. Knoller, L. Ouziel-Yahalom, and S. Efrat, “HES-1 is involved in adaptation of adult human β-cells to proliferation in vitro,” Diabetes, vol. 57, no. 9, pp. 2413–2420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Bauman, R. Higdon, S. Rapson et al., “Design and initial characterization of the SC-200 proteomics standard mixture,” OMICS, vol. 15, no. 1-2, pp. 73–82, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Gu, J. Dubauskaite, and D. A. Melton, “Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors,” Development, vol. 129, no. 10, pp. 2447–2457, 2002. View at Google Scholar · View at Scopus