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Stem Cells International
Volume 2016, Article ID 6409546, 12 pages
Research Article

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells

1National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China
2Center of Digital Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
32nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China
4Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
5Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China

Received 18 December 2015; Revised 28 February 2016; Accepted 4 April 2016

Academic Editor: Jiabing Fan

Copyright © 2016 Qing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.