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Stem Cells International
Volume 2016 (2016), Article ID 6484713, 10 pages
http://dx.doi.org/10.1155/2016/6484713
Review Article

The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China

Received 5 September 2015; Revised 23 November 2015; Accepted 26 November 2015

Academic Editor: Luciano Vellon

Copyright © 2016 Nina Xie and Beisha Tang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In principle, induced pluripotent stem cells (iPSCs) are generated from somatic cells by reprogramming and gaining the capacity to self-renew indefinitely as well as the ability to differentiate into cells of different lineages. Human iPSCs have absolute advantages over human embryonic stem cells (ESCs) and animal models in disease modeling, drug screening, and cell replacement therapy. Since Takahashi and Yamanaka first described in 2007 that iPSCs can be generated from human adult somatic cells by retroviral transduction of the four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, disease specific iPSC lines have sprung up worldwide like bamboo shoots after a spring rain, making iPSC one of the hottest and fastest moving topics in modern science. The craze for iPSCs has spread throughout main branches of clinical medicine, covering neurology, hematology, cardiology, endocrinology, hepatology, ophthalmology, and so on. Here in this paper, we will focus on the clinical application of human iPSCs in disease modeling, drug screening, and cell replacement therapy for neurological diseases.