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Stem Cells International
Volume 2016 (2016), Article ID 7231038, 7 pages
Review Article

Innovative Dental Stem Cell-Based Research Approaches: The Future of Dentistry

Orofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland

Received 11 April 2016; Revised 15 June 2016; Accepted 12 July 2016

Academic Editor: Bernard A. J. Roelen

Copyright © 2016 Shayee Miran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Over the past decade, the dental field has benefited from recent findings in stem cell biology and tissue engineering that led to the elaboration of novel ideas and concepts for the regeneration of dental tissues or entire new teeth. In particular, stem cell-based regenerative approaches are extremely promising since they aim at the full restoration of lost or damaged tissues, ensuring thus their functionality. These therapeutic approaches are already applied with success in clinics for the regeneration of other organs and consist of manipulation of stem cells and their administration to patients. Stem cells have the potential to self-renew and to give rise to a variety of cell types that ensure tissue repair and regeneration throughout life. During the last decades, several adult stem cell populations have been isolated from dental and periodontal tissues, characterized, and tested for their potential applications in regenerative dentistry. Here we briefly present the various stem cell-based treatment approaches and strategies that could be translated in dental practice and revolutionize dentistry.