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Stem Cells International
Volume 2016 (2016), Article ID 8235172, 12 pages
http://dx.doi.org/10.1155/2016/8235172
Research Article

Regulatory Mechanisms of the Ihh/PTHrP Signaling Pathway in Fibrochondrocytes in Entheses of Pig Achilles Tendon

1Department of Orthopedics, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China
2Center of Joint Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China

Received 20 July 2016; Accepted 15 September 2016

Academic Editor: Kai Tao

Copyright © 2016 Xuesong Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Benjamin, T. Kumai, S. Milz, B. M. Boszczyk, A. A. Boszczyk, and J. R. Ralphs, “The skeletal attachment of tendons—tendon ‘entheses’,” Comparative Biochemistry and Physiology—A Molecular and Integrative Physiology, vol. 133, no. 4, pp. 931–945, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Kitay and S. W. Wolfe, “Scapholunate instability: current concepts in diagnosis and management,” Journal of Hand Surgery, vol. 37, no. 10, pp. 2175–2196, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Vinardell, R. A. Rolfe, C. T. Buckley et al., “Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells,” European Cells and Materials, vol. 23, pp. 121–134, 2012. View at Google Scholar · View at Scopus
  4. H. T. J. Gilbert, J. A. Hoyland, A. J. Freemont, and S. J. Millward-Sadler, “The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration,” Arthritis Research and Therapy, vol. 13, no. 1, article R8, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. R. M. Schulz and A. Bader, “Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes,” European Biophysics Journal, vol. 36, no. 4-5, pp. 539–568, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. J. C. Y. Fan and S. D. Waldman, “The effect of intermittent static biaxial tensile strains on tissue engineered cartilage,” Annals of Biomedical Engineering, vol. 38, no. 4, pp. 1672–1682, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. P. Grogan, S. Sovani, C. Pauli et al., “Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels,” Tissue Engineering—Part A, vol. 18, no. 17-18, pp. 1784–1792, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Miao, B. He, Y. Jiang et al., “Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34,” The Journal of Clinical Investigation, vol. 115, no. 9, pp. 2402–2411, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. C. C. Van Donkelaar and R. Huiskes, “The PTHrP-Ihh feedback loop in the embryonic growth plate allows PTHrP to control hypertrophy and Ihh to regulate proliferation,” Biomechanics and Modeling in Mechanobiology, vol. 6, no. 1-2, pp. 55–62, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. R. G. Susperregui, F. Viñals, P. W. M. Ho, M. T. Gillespie, T. J. Martin, and F. Ventura, “BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells,” Journal of Cellular Physiology, vol. 216, no. 1, pp. 144–152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. L. P. Lai, K. A. DaSilva, and J. Mitchell, “Regulation of Indian hedgehog mRNA levels in chondrocytic cells by ERK1/2 and p38 mitogen-activated protein kinases,” Journal of Cellular Physiology, vol. 203, no. 1, pp. 177–185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. J. Hilton, X. Tu, and F. Long, “Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage,” Developmental Biology, vol. 308, no. 1, pp. 93–105, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Kohn, Y. Dong, A. J. Mirando et al., “Cartilage-specific RBPjκ-dependent and independent notch signals regulate cartilage and bone development,” Development, vol. 139, no. 6, pp. 1198–1212, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Han, W. Wang, Y. Zhuang, Z. Zhang, and Q. Chen, “Isolation, cultivation and identification method of fibrochondrocytes from fibrocartilaginous enthesis of the Guizhou mini pig's achilles,” Orthopedic Journal of China, vol. 22, no. 18, pp. 1685–1690, 2014. View at Google Scholar
  15. K. Lenton, A. W. James, A. Manu et al., “Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling,” Genesis, vol. 49, no. 10, pp. 751–752, 2011. View at Publisher · View at Google Scholar
  16. K. Lenton, A. W. James, A. Manu et al., “Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling,” Genesis, vol. 49, no. 10, pp. 784–796, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Chen, C. M. Macica, A. Nasiri, and A. E. Broadus, “Regulation of articular chondrocyte proliferation and differentiation by Indian hedgehog and parathyroid hormone-related protein in mice,” Arthritis and Rheumatism, vol. 58, no. 12, pp. 3788–3797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Van Der Horst, H. Farih-Sips, C. W. G. M. Löwik, and M. Karperien, “Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 cells,” Journal of Bone and Mineral Research, vol. 20, no. 12, pp. 2233–2244, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. E. C. Weir, W. M. Philbrick, M. Amling, L. A. Neff, R. Baron, and A. E. Broadus, “Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 19, pp. 10240–10245, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. R. J. O'Keefe, L. S. Loveys, D. G. Hicks et al., “Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes,” Journal of Orthopaedic Research, vol. 15, no. 2, pp. 162–174, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Guo, J. Zhou, B. Gao et al., “Missense mutations in IHH impair Indian hedgehog signaling in C3H10T1/2 cells: implications for brachydactyly type A1, and new targets for hedgehog signaling,” Cellular and Molecular Biology Letters, vol. 15, no. 1, pp. 153–176, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Ma, J. Yu, Y. Xiao et al., “Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels,” Cell Research, vol. 21, no. 9, pp. 1343–1357, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Vortkamp, K. Lee, B. Lanske, G. V. Segre, H. M. Kronenberg, and C. J. Tabin, “Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein,” Science, vol. 273, no. 5275, pp. 613–622, 1996. View at Google Scholar
  24. B. Lanske, A. C. Karaplis, K. Lee et al., “PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth,” Science, vol. 273, no. 5275, pp. 663–666, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. P. W. Ingham and A. P. McMahon, “Hedgehog signaling in animal development: paradigms and principles,” Genes and Development, vol. 15, no. 23, pp. 3059–3087, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. S. J. Karp, E. Schipani, B. St-Jacques, J. Hunzelman, H. Kronenberg, and A. P. McMahon, “Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways,” Development, vol. 127, no. 3, pp. 543–548, 2000. View at Google Scholar · View at Scopus
  27. M. El-Zaatari, A. M. Grabowska, A. J. McKenzie, D. G. Powe, P. J. Scotting, and S. A. Watson, “Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition,” Regulatory Peptides, vol. 146, no. 1–3, pp. 131–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J.-Y. Wu, A.-F. Xu, L. Xu et al., “Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro,” Hepato-Gastroenterology, vol. 58, no. 110-111, pp. 1511–1518, 2011. View at Google Scholar · View at Scopus
  29. K. Nybakken and N. Perrimon, “Hedgehog signal transduction: recent findings,” Current Opinion in Genetics and Development, vol. 12, no. 5, pp. 503–511, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. K. K. Mak, Y. Bi, C. Wan et al., “Hedgehog Signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression,” Developmental Cell, vol. 14, no. 5, pp. 674–688, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Shimoyama, M. Wada, F. Ikeda et al., “Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function,” Molecular Biology of the Cell, vol. 18, no. 7, pp. 2411–2418, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. K. K. Mak, H. M. Kronenberg, P.-T. Chuang, S. Mackem, and Y. Yang, “Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy,” Development, vol. 135, no. 11, pp. 1947–1956, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. B. J. Swalla, W. B. Upholt, and M. Solursh, “Analysis of type II collagen RNA localization in chick wing buds by in situ hybridization,” Developmental Biology, vol. 125, no. 1, pp. 51–58, 1988. View at Publisher · View at Google Scholar · View at Scopus