Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016 (2016), Article ID 8357567, 12 pages
http://dx.doi.org/10.1155/2016/8357567
Research Article

Hepatic Stellate Cell-Derived Microvesicles Prevent Hepatocytes from Injury Induced by APAP/H2O2

1Department of Hepatobiliary Surgery, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
2Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China

Received 28 December 2015; Accepted 31 March 2016

Academic Editor: Gary E. Lyons

Copyright © 2016 Renwei Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Lambrecht, I. Mannaerts, and L. A. van Grunsven, “The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis,” Frontiers in Physiology, vol. 6, article 209, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. S. L. Friedman, “Liver fibrosis—from bench to bedside,” Journal of Hepatology, Supplement, vol. 38, supplement 1, pp. S38–S53, 2003. View at Google Scholar · View at Scopus
  3. U. E. Lee and S. L. Friedman, “Mechanisms of hepatic fibrogenesis,” Best Practice and Research: Clinical Gastroenterology, vol. 25, no. 2, pp. 195–206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. R. S. Rahimi and D. C. Rockey, “Complications and outcomes in chronic liver disease,” Current Opinion in Gastroenterology, vol. 27, no. 3, pp. 204–209, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. R. S. Rahimi and D. C. Rockey, “Complications of cirrhosis,” Current Opinion in Gastroenterology, vol. 28, no. 3, pp. 223–229, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Y. Tan, R. C. Lai, W. Wong, Y. Y. Dan, S.-K. Lim, and H. K. Ho, “Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models,” Stem Cell Research and Therapy, vol. 5, no. 3, article 76, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. V. J. Navarro and J. R. Senior, “Drug-related hepatotoxicity,” The New England Journal of Medicine, vol. 354, no. 7, pp. 731–739, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Biancofiore and C. L. Davis, “Renal dysfunction in the perioperative liver transplant period,” Current Opinion in Organ Transplantation, vol. 13, no. 3, pp. 291–297, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Mukherjee, J. F. Botha, and U. Mukherjee, “Immunosuppression in liver transplantation,” Current Drug Targets, vol. 10, no. 6, pp. 557–574, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Kordes, I. Sawitza, S. Götze, D. Herebian, and D. Häussinger, “Hepatic stellate cells contribute to progenitor cells and liver regeneration,” The Journal of Clinical Investigation, vol. 124, no. 12, pp. 5503–5515, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. I. Mederacke, C. C. Hsu, J. S. Troeger et al., “Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology,” Nature Communications, vol. 4, article 2823, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Geerts, “History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells,” Seminars in Liver Disease, vol. 21, no. 3, pp. 311–335, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. X. P. Pan, Y. Wang, X. P. Yu et al., “Establishment and characterization of an immortalized human hepatic stellate cell line for applications in co-culturing with immortalized human hepatocytes,” International Journal of Medical Sciences, vol. 12, no. 3, pp. 248–255, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. V. V. Kalinichenko, D. Bhattacharyya, Y. Zhou et al., “Foxf1 +/− mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury,” Hepatology, vol. 37, no. 1, pp. 107–117, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Itaba, Y. Matsumi, K. Okinaka et al., “Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice,” Scientific Reports, vol. 5, article 16169, 2015. View at Publisher · View at Google Scholar
  16. J. J. Maher, “Cell-specific expression of hepatocyte growth factor in liver: upregulation in sinusoidal endothelial cells after carbon tetrachloride,” The Journal of Clinical Investigation, vol. 91, no. 5, pp. 2244–2252, 1993. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Cantaluppi, S. Gatti, D. Medica et al., “Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells,” Kidney International, vol. 82, no. 4, pp. 412–427, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Xin, Y. Li, Y. Cui, J. J. Yang, Z. G. Zhang, and M. Chopp, “Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats,” Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 11, pp. 1711–1715, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Reinke and H. Sorg, “Wound repair and regeneration,” European Surgical Research, vol. 49, no. 1, pp. 35–43, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Weilner, E. Schraml, H. Redl, R. Grillari-Voglauer, and J. Grillari, “Secretion of microvesicular miRNAs in cellular and organismal aging,” Experimental Gerontology, vol. 48, no. 7, pp. 626–633, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Gu, W. Zhang, J. Chen et al., “EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis,” PLoS ONE, vol. 9, no. 1, Article ID e85396, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Castilho-Fernandes, D. C. de Almeida, A. M. Fontes et al., “Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells,” Experimental and Molecular Pathology, vol. 91, no. 3, pp. 664–672, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Liu, Q. Pan, Y. Zhao et al., “MicroRNA-155 regulates ROS production, NO generation,apoptosis and multiple functions of human brain microvessel endothelial cells under physiological and pathological conditions,” Journal of Cellular Biochemistry, vol. 116, no. 2, pp. 2870–2881, 2015. View at Publisher · View at Google Scholar
  24. J. Gao, C. Zhang, X. Fu et al., “Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons,” PLoS ONE, vol. 8, no. 5, Article ID e63084, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. G. H. Tang, H. Y. Yang, J. C. Zhang et al., “Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function,” World Journal of Gastroenterology, vol. 21, no. 43, pp. 12370–12380, 2015. View at Publisher · View at Google Scholar
  26. S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, “In vitro toxicity of nanoparticles in BRL 3A rat liver cells,” Toxicology in Vitro, vol. 19, no. 7, pp. 975–983, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. R. S. McCuskey, “The hepatic microvascular system in health and its response to toxicants,” Anatomical Record, vol. 291, no. 6, pp. 661–671, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Koopman, C. P. M. Reutelingsperger, G. A. M. Kuijten, R. M. J. Keehnen, S. T. Pals, and M. H. J. van Oers, “Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis,” Blood, vol. 84, no. 5, pp. 1415–1420, 1994. View at Google Scholar · View at Scopus
  29. S. F. Mause and C. Weber, “Microparticles: protagonists of a novel communication network for intercellular information exchange,” Circulation Research, vol. 107, no. 9, pp. 1047–1057, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. J. He, Y. Wang, S. Sun et al., “Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model,” Nephrology, vol. 17, no. 5, pp. 493–500, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Bruno, C. Grange, M. C. Deregibus et al., “Mesenchymal stem cell-derived microvesicles protect against acute tubular injury,” Journal of the American Society of Nephrology, vol. 20, no. 5, pp. 1053–1067, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. L. L. Meyers, W. P. Beierschmitt, E. A. Khairallah, and S. D. Cohen, “Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice,” Toxicology and Applied Pharmacology, vol. 93, no. 3, pp. 378–387, 1988. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Y. Tan, T. Y. Saw, C. W. Fong, and H. K. Ho, “Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury,” Redox Biology, vol. 4, pp. 308–320, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Zhou, M. M. Tabb, A. Sadatrafiei, F. Grün, and B. Blumberg, “Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes,” Drug Metabolism and Disposition, vol. 32, no. 10, pp. 1075–1082, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. Z. Liu, S. Que, H. Ning, L. Wang, and T. Peng, “Elevated alanine aminotransferase is strongly associated with incident metabolic syndrome: a meta-analysis of prospective studies,” PLoS ONE, vol. 8, no. 12, Article ID e80596, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. I. Park, J. Ryuk, H. Lee, H. Go, and B. Ko, “In vitro and in vivo effects of ethanol extract combined with Curcumae Radix and Glycyrrhizae Radix et Rhizoma on menopausal metabolic disturbances,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 9, pp. 15076–15086, 2015. View at Google Scholar