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Stem Cells International
Volume 2016 (2016), Article ID 8419104, 7 pages
Review Article

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy

Received 7 December 2015; Accepted 20 March 2016

Academic Editor: Pura Muñoz-Cánoves

Copyright © 2016 Luca Genovese and Andrea Brendolan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.