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Stem Cells International
Volume 2017, Article ID 1479137, 7 pages
https://doi.org/10.1155/2017/1479137
Research Article

Maintenance of a Schwann-Like Phenotype in Differentiated Adipose-Derived Stem Cells Requires the Synergistic Action of Multiple Growth Factors

1Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK
2Department of Biophysics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
3Department of Plastic Surgery & Burns, University Hospitals of South Manchester, Manchester Academic Health Science Centre, Manchester, UK

Correspondence should be addressed to Adam J. Reid; ku.ca.retsehcnam@dier.mada

Received 7 April 2017; Accepted 16 May 2017; Published 16 July 2017

Academic Editor: Marco A. Velasco-Velazquez

Copyright © 2017 Alice E. Mortimer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Faroni, S. A. Mobasseri, P. J. Kingham, and A. J. Reid, “Peripheral nerve regeneration: experimental strategies and future perspectives,” Advanced Drug Delivery Reviews, vol. 82, pp. 160–167, 2015. View at Google Scholar
  2. P. J. Kingham, D. F. Kalbermatten, D. Mahay, S. J. Armstrong, M. Wiberg, and G. Terenghi, “Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro,” Experimental Neurology, vol. 207, no. 2, pp. 267–274, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Kern, H. Eichler, J. Stoeve, H. Klüter, and K. Bieback, “Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue,” Stem Cells, vol. 24, no. 5, pp. 1294–1301, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Faroni, S. RJP, L. Lu, and A. J. Reid, “Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium,” The European Journal of Neuroscience, vol. 43, no. 3, pp. 417–430, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. K. R. Jessen and R. Mirsky, “Signals that determine Schwann cell identity,” Journal of Anatomy, vol. 200, no. 4, pp. 367–376, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Syed and H. A. Kim, “Soluble neuregulin and Schwann cell myelination: a therapeutic potential for improving remyelination of adult axons,” Molecular and Cellular Pharmacology, vol. 2, no. 4, pp. 161–167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Orbay, C. J. Little, L. Lankford, C. A. Olson, and D. E. Sahar, “The key components of Schwann cell-like differentiation medium and their effects on gene expression pattern of adipose-derived stem cells,” Annals of Plastic Surgery, vol. 74, no. 5, pp. 584–588, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. J. B. Davis and P. Stroobant, “Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells,” The Journal of Cell Biology, vol. 110, no. 4, pp. 1353–1360, 1990. View at Publisher · View at Google Scholar
  9. A. Kabiri, E. Esfandiari, B. Hashemibeni, M. Kazemi, M. Mardani, and A. Esmaeili, “Effects of FGF-2 on human adipose tissue derived adult stem cells morphology and chondrogenesis enhancement in transwell culture,” Biochemical and Biophysical Research Communications, vol. 424, no. 2, pp. 234–238, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. R. H. Alasbahi and M. F. Melzig, “Forskolin and derivatives as tools for studying the role of cAMP,” Pharmazie, vol. 67, no. 1, pp. 5–13, 2012. View at Google Scholar
  11. K. H. Tse, L. N. Novikov, M. Wiberg, and P. J. Kingham, “Intrinsic mechanisms underlying the neurotrophic activity of adipose derived stem cells,” Experimental Cell Research, vol. 331, no. 1, pp. 142–151, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Taveggia, G. Zanazzi, A. Petrylak et al., “Neuregulin-1 type III determines the ensheathment fate of axons,” Neuron, vol. 47, no. 5, pp. 681–694, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. M. Stassart, R. Fledrich, V. Velanac et al., “A role for Schwann cell-derived neuregulin-1 in remyelination,” Nature Neuroscience, vol. 16, no. 1, pp. 48–54, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Birchmeier and D. L. H. Bennett, “Neuregulin/ErbB signaling in developmental myelin formation and nerve repair,” Current Topics in Developmental Biology, vol. 116, pp. 45–64, 2016. View at Google Scholar
  15. Y. Yarden and M. X. Sliwkowski, “Untangling the ErbB signalling network,” Nature Reviews. Molecular Cell Biology, vol. 2, no. 2, pp. 127–137, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Napoli, L. A. Noon, S. Ribeiro et al., “A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo,” Neuron, vol. 73, no. 4, pp. 729–742, 2012. View at Publisher · View at Google Scholar · View at Scopus