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Stem Cells International
Volume 2017 (2017), Article ID 1653254, 13 pages
Review Article

Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

1Laboratory of Stem Cells’ Biology, Department of Human Immunology, Chair of Preclinical Studies, Institute of Experimental and Clinical Medicine, Faculty of Medicine, University of Rzeszow, Ul. Kopisto 2a, 35-310 Rzeszow, Poland
2Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Ul. Warzywna 1a, 35-310 Rzeszow, Poland
3Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan

Correspondence should be addressed to Agnieszka Banaś-Ząbczyk

Received 10 February 2017; Revised 28 April 2017; Accepted 14 May 2017; Published 5 July 2017

Academic Editor: Mustapha Najimi

Copyright © 2017 Beata Kocan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There has been an increased interest in mesenchymal stem cells from adipose tissue, due to their abundance and accessibility with no ethical concerns. Their multipotent properties make them appropriate for regenerative clinical applications. It has been shown that adipose-derived stem cells (ASCs) may differ between the origin sites. Moreover, a variety of internal and external factors may affect their biological characteristics, as what we aimed to highlight in this review. It has been demonstrated that ASCs secrete multiple trophic factors that are capable of stimulating cell proliferation and differentiation and migration of various cell types. Particular attention should be given to exosomes, since it is known that they contribute to the paracrine effects of MSCs. Secretion of trophic agents by ASCs is thought to be in a greater importance for regenerative medicine applications, rather than cells engraftment to the site of injury and their differentiation ability. The surface marker profile of ASCs seems to be similar to that of the mesenchymal stem cells from bone marrow, although some molecular differences are observed. Thus, in this review, we have attempted to define trophic activity, as well as phenotypic characterization of ASCs, as crucial factors for therapeutic usage.