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Stem Cells International
Volume 2017 (2017), Article ID 1764549, 12 pages
https://doi.org/10.1155/2017/1764549
Research Article

Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells

1Stem Cell and Cancer Center, The First Bethune Hospital, Jilin University, Changchun, Jilin 130061, China
2Stanford University Medical School, Palo Alto Veterans Institute for Research, Palo Alto, CA 94304, USA
3Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA

Correspondence should be addressed to Pinchas Cohen, Jiuwei Cui, Andrew R. Hoffman, and Ji-Fan Hu

Received 18 October 2016; Revised 5 January 2017; Accepted 16 January 2017; Published 6 April 2017

Academic Editor: Martin Stimpfel

Copyright © 2017 Dehai Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

File 1: The ECM pathway in senescent MSCs. File 2: The AKT pathway in senescent HMSCs. File 3: mtDNA methylation of other CpG sites in senescent HMSCs. File 4: mtDNA methylation of other CpG sites in senescent SMSCs. File 5: mtDNA methylation of other CpG sites in old fibroblasts. File 6: PCR oligonucleotide primers.

  1. Supplementary Material