Stem Cells International

Mitochondria: More than Just “Power Plants” in Stem Cells


Status
Published

Lead Editor

1University Medical Centre Ljubljana, Ljubljana, Slovenia

2University of Eastern Finland, Kuopio, Finland

3Centre Hospitalier Universitaire d'Angers, Angers, France


Mitochondria: More than Just “Power Plants” in Stem Cells

Description

Primary role of mitochondria is to provide energy to cells in the form of ATP via oxidative phosphorylation. But besides ATP, which is the main product of this metabolic process, also by-products are generated such as reactive oxygen species, for instance. These by-products can have serious detrimental effects on cells since they can damage DNA and even oxidize lipids and proteins. The mitochondria are also special since they are besides nucleus the only organelle in animal and human cell with DNA and despite the fact this DNA codes only 37 genes, this suggests they have a special position in navigating the life and faith of a cell. The importance of mitochondria/mitochondrial DNA (mtDNA) is also reflected in the fact that even minor mtDNA mutations can cause lethal diseases.

Similarly as in differentiated cells, the special role of mitochondria was revealed in stem cells. Stem cells have specific distribution and metabolic profile of mitochondria and the changes of these features are correlated with differentiation of stem cells or reprogramming of somatic cells. Recently the influence of mtDNA mutations in generating induced pluripotent stem cells (iPSCs) due to aging was highlighted and it raised concerns about using iPSCs in cell therapies and regenerative medicine. These are just few of the reasons why mitochondria should be in more detail studied in stem cells and since the main aim of stem cell research is in fact to use stem cells in cell therapies and regenerative medicine, these issues should be clarified as much as possible to provide safe treatments.

The aim of this special issue is to answer some aspects of these important questions and to summarize the most recent and advanced developments and approaches on this field. We invite researchers to contribute high quality original research articles as well as review articles.

Potential topics include but are not limited to the following:

  • The role of mitochondria on stem cell fate and stem cell differentiation
  • The impact of mitochondria on stem cell therapies and regenerative medicine
  • The influence of mtDNA mutations on stem cells
  • Metabolic changes in mitochondria during reprogramming
  • The mitochondria as an obstacle in reprogramming of somatic cells
  • The importance of mitochondria in reproductive medicine
  • Replacing of old mitochondria with younger ones as a therapeutic strategy (in regenerative and in reproductive medicine)
  • Mitochondria as therapeutic target in cancer treatment via targeting mitochondria in cancer stem cells

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 1826746
  • - Editorial

Mitochondria: More than Just “Power Plants” in Stem Cells

Martin Stimpfel | Riikka H. Hämäläinen | Pascal May-Panloup
  • Special Issue
  • - Volume 2017
  • - Article ID 2874283
  • - Review Article

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

Jarmon G. Lees | David K. Gardner | Alexandra J. Harvey
  • Special Issue
  • - Volume 2017
  • - Article ID 7068567
  • - Review Article

Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells

D. C. Woods
  • Special Issue
  • - Volume 2017
  • - Article ID 7610414
  • - Review Article

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

Andrés Caicedo | Pedro M. Aponte | ... | Maroun Khoury
  • Special Issue
  • - Volume 2017
  • - Article ID 6917941
  • - Review Article

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

Marie-Luce Vignais | Andrés Caicedo | ... | Christian Jorgensen
  • Special Issue
  • - Volume 2017
  • - Article ID 8073721
  • - Review Article

Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer

Javier Prieto | Josema Torres
  • Special Issue
  • - Volume 2017
  • - Article ID 1764549
  • - Research Article

Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells

Dehai Yu | Zhonghua Du | ... | Ji-Fan Hu
Stem Cells International
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Acceptance rate44%
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CiteScore7.200
Impact Factor3.869
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