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Stem Cells International
Volume 2017, Article ID 2389753, 15 pages
Research Article

Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function

1Institute of Parasitology and Biomedicine “López-Neyra”, CSIC, PTS, Granada, Spain
2GENYO, Centre of Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, Spain
3School of Medicine, Department of Pathology, IBIMER, CIBM, University of Granada, Granada, Spain

Correspondence should be addressed to Per Anderson; se.oyneg@nosredna.rep and Mario Delgado; se.cisc.bpi@odagledm

Received 17 October 2016; Accepted 18 December 2016; Published 30 January 2017

Academic Editor: Marcella Franquesa

Copyright © 2017 Per Anderson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

S1 Fig. Mitomycin-C treatment does not affect to suppressive activity of mASCs.

S2 Fig. mASCs and DCs express iNOS upon stimulation.

S3 Fig. Representative dot plots showing the intracellular staining of IFN-γ and IL-17 in DLN cells from EAE and mASC-treated mice.

S4 Fig. Representative dot plots showing the expression of CD40, CD80 and CD86 on LPS-stimulated CD11c+ DCs cultured with or without mASCs.

S5 Fig. Representative dot plots showing intracellular TNF-α in DCs isolated from EAE or mASC-treated mice.

S6 Fig. Arginase activity is induced in mASC:splenocyte cocultures.

  1. Supplementary Material