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Stem Cells International
Volume 2017, Article ID 2480375, 10 pages
https://doi.org/10.1155/2017/2480375
Review Article

An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

1Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
2Paul and Sheila Wellstone Muscular Dystrophy Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
3Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA

Correspondence should be addressed to Atsushi Asakura; ude.nmu@arukasa

Received 12 January 2017; Revised 1 April 2017; Accepted 18 April 2017; Published 30 May 2017

Academic Editor: Ninghui Cheng

Copyright © 2017 Alexander Hron and Atsushi Asakura. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.