Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2017, Article ID 2653142, 7 pages
Review Article

Stem and Progenitor Cells in Human Cardiopulmonary Development and Regeneration

1Swiss Institute for Regenerative Medicine, Foundation for Cardiological Research and Education, Via ai Söi 24, 6807 Taverne, Switzerland
2Cardiology Department, Cardiocentro Ticino Foundation, Via Tesserete 48, 6900 Lugano, Switzerland

Correspondence should be addressed to Silvana Bardelli; gro.ortnecoidrac@illedrab.anavlis

Received 28 April 2017; Accepted 15 August 2017; Published 17 September 2017

Academic Editor: Fatemeh Sharifpanah

Copyright © 2017 Silvana Bardelli and Marco Moccetti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Already during embryonic development, the heart and the lung are thoroughly connected organs. Their interdependence allows our survival in the terrestrial environment by coupling cardiac output and gas exchange. The knowledge on developmental processes involving stem and progenitor cells is crucial to understand the onset of human cardiopulmonary diseases. The precise identification of various adult endogenous progenitors is still incomplete. Thus, caution should be exercised on newly available stem cell-based treatments until specific mechanisms of action are disclosed. The objective is to provide in the nearest future feasible and safer cell therapeutics for the complex pathological condition of human cardiopulmonary diseases. In this paper, we highlight the significant knowledge advancement concerning stem and progenitor cells in the cardiopulmonary field: from embryonic development to adult progenitors until early preclinical models for cardiopulmonary regeneration.