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Stem Cells International
Volume 2017, Article ID 4045238, 6 pages
Review Article

Osteopontin: Relation between Adipose Tissue and Bone Homeostasis

1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
2Department of Medicine, University of Padua, Padua, Italy
3Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

Correspondence should be addressed to Giovanni Messina; ti.2aninu@anissem.innaig

Received 29 April 2016; Revised 19 November 2016; Accepted 18 December 2016; Published 17 January 2017

Academic Editor: Armand Keating

Copyright © 2017 Carolina De Fusco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.