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Stem Cells International
Volume 2017 (2017), Article ID 4130607, 16 pages
Review Article

Advances and Prospects in Stem Cells for Cartilage Regeneration

1Institute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing 100853, China
2Anesthesiology Department, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China
3Medical College, Nankai University, Tianjin, 300071, China
4Center for Biomedical Material and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

Correspondence should be addressed to Shuyun Liu; moc.361@nna_raelc and Quanyi Guo; moc.361@103_ougrotcod

Received 22 July 2016; Revised 24 November 2016; Accepted 26 December 2016; Published 26 January 2017

Academic Editor: Jianying Zhang

Copyright © 2017 Mingjie Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion. Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. Much research has examined cartilage regeneration utilizing stem cells. However, both the potential and the limitations of this procedure remain controversial. This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engineering and regenerative medicine. In particular, it focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies and approaches involving stem cells that have been used in cartilage repair and clinical studies. Based on the research into chondrocyte and stem cell technologies, this review discusses the damage and repair of cartilage and the clinical application of stem cells, with a view to increasing our systematic understanding of the application of stem cells in cartilage regeneration; additionally, several advanced strategies for cartilage repair are discussed.