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Stem Cells International
Volume 2017, Article ID 4276927, 9 pages
Review Article

Environmental Factors That Influence Stem Cell Migration: An “Electric Field”

1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5S 3E1
2Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada M4G 3V9
3Department of Surgery, University of Toronto, Toronto, ON, Canada M5S 3E1

Correspondence should be addressed to Cindi M. Morshead; ac.otnorotu@daehsrom.idnic

Received 26 January 2017; Revised 21 March 2017; Accepted 11 April 2017; Published 15 May 2017

Academic Editor: Alfredo Garcia

Copyright © 2017 Stephanie N. Iwasa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Environmental Stimulus of Electric Fields on Stem Cell Migration. The movement of cells in response to electric potential gradients is called galvanotaxis. In vivo galvanotaxis, powered by endogenous electric fields (EFs), plays a critical role during development and wound healing. This review aims to provide a perspective on how stem cells transduce EFs into directed migration and an understanding of the current literature relating to the mechanisms by which cells sense and transduce EFs. We will comment on potential EF-based regenerative medicine therapeutics.