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Stem Cells International
Volume 2017, Article ID 5160261, 12 pages
https://doi.org/10.1155/2017/5160261
Review Article

Functional Test Scales for Evaluating Cell-Based Therapies in Animal Models of Spinal Cord Injury

Department of Biomedical Sciences, Korea University College of Medicine, Seoul 136-705, Republic of Korea

Correspondence should be addressed to Woon Ryoung Kim; rk.ca.aerok@mikrw and Dongho Geum; rk.ca.aerok@dmueg

Received 5 April 2017; Revised 28 June 2017; Accepted 1 August 2017; Published 4 October 2017

Academic Editor: Ivan Velasco

Copyright © 2017 Woon Ryoung Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recently, spinal cord researchers have focused on multifaceted approaches for the treatment of spinal cord injury (SCI). However, as there is no cure for the deficits produced by SCI, various therapeutic strategies have been examined using animal models. Due to the lack of standardized functional assessment tools for use in such models, it is important to choose a suitable animal model and precise behavioral test when evaluating the efficacy of potential SCI treatments. In the present review, we discuss recent evidence regarding functional recovery in various animal models of SCI, summarize the representative models currently used, evaluate recent cell-based therapeutic approaches, and aim to identify the most precise and appropriate scales for functional assessment in such research.