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Stem Cells International
Volume 2017, Article ID 5270527, 8 pages
https://doi.org/10.1155/2017/5270527
Research Article

Paracrine Effects of Bone Marrow Mononuclear Cells in Survival and Cytokine Expression after 90% Partial Hepatectomy

1Experimental Laboratory of Gastroenterology and Hepatology, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil
2Post-Graduation Program on Medicine: Sciences in Gastroenterology, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil
3Gene Therapy Center, HCPA, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil
4Post-Graduation Program on Genetics and Molecular Biology, UFRGS, Av. Bento Gonçalves 9500, 91501-970 Porto Alegre, RS, Brazil
5Post-Graduation Program in Surgery, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil
6Post-Graduation Program in Child and Adolescent Health, UFRGS, Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil

Correspondence should be addressed to Ursula Matte; rb.ude.apch@ettamu

Received 23 September 2016; Revised 30 November 2016; Accepted 10 January 2017; Published 23 February 2017

Academic Editor: Dario Coletti

Copyright © 2017 Carlos Oscar Kieling et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Serum level of Interleukin 6 (IL-6) was measured in blood collected at the time of death in rats receiving empty capsules (EC group) or capsules containing bone marrow mononuclear cells (BMMC group) after 90% partial hepatectomy (90% PH). Serum level of IL-6 was quantified by enzyme-linked immunosorbent assay (ELISA) using commercial kits (R&D Systems, Minneapolis, Minnesota, EUA) in accordance with the manufacturer’s instructions. Both groups showed a significant increase of IL-6 at 6h post 90%PH, with progressive reduction to normal range after 12 h. No statistical difference was observed between groups.

  1. Supplementary Material