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Stem Cells International
Volume 2017, Article ID 6305295, 10 pages
Review Article

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

1Gynecology and Oncology Department of the Second Hospital of Jilin University, Ziqiang Street 218, Changchun 130000, China
2Medical Research Center, Second Clinical College, Jilin University, Ziqiang Street 218, Changchun 130000, China

Correspondence should be addressed to Tianmin Xu; moc.621@nimnaitux

Received 11 August 2017; Revised 5 November 2017; Accepted 22 November 2017; Published 19 December 2017

Academic Editor: Changwon Park

Copyright © 2017 Lin Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mesenchymal stem cells have been at the forefront of regenerative medicine for many years. Exosomes, which are nanovesicles involved in intercellular communication and the transportation of genetic material transportation that can be released by mesenchymal stem cells, have been recently reported to play a role in cell-free therapy of many diseases, including myocardial infarction, drug addiction, and status epilepticus. They are also thought to help ameliorate inflammation-induced preterm brain injury, liver injury, and various types of cancer. This review highlights recent advances in the exploration of mesenchymal stem cell-derived exosomes in therapeutic applications. The natural contents, drug delivery potency, modification methods, and drug loading methods of exosomes are also discussed.