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Stem Cells International
Volume 2017, Article ID 6374504, 10 pages
Review Article

Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation

1Institute for Biomedical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, Republic of Korea
2Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Republic of Korea
3Department of Integrated Omics for Biomedical Sciences, Yonsei University, Seoul, Republic of Korea

Correspondence should be addressed to Soyeon Lim; and Ki-Chul Hwang;

Received 27 April 2017; Revised 12 July 2017; Accepted 2 August 2017; Published 30 August 2017

Academic Editor: Mark W. Hamrick

Copyright © 2017 Seahyoung Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required. Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important. Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance. Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation. Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future.