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Stem Cells International
Volume 2017, Article ID 6825427, 6 pages
Review Article

Noncoding RNA and Cardiomyocyte Proliferation

Department of Cardiology, Chongqing Institute of Cardiology & Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, Chongqing 400042, China

Correspondence should be addressed to Chunyu Zeng; moc.361@10gnezuynuhc and Wei Eric Wang; moc.361@gnawcireiew

Received 30 June 2017; Accepted 20 August 2017; Published 31 October 2017

Academic Editor: Yaoliang Tang

Copyright © 2017 Shuang Qu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is acknowledged that postnatal mammalian cardiomyocytes (CMs) turn over with a very limited efficacy in both physiological and pathological conditions. Recent studies showed that those newly formed CMs are derived from preexisting CMs. Thus, stimulating CM proliferation becomes a promising strategy for inducing cardiac regeneration. Noncoding RNAs were found differently expressed in CMs with different proliferation potential. Moreover, manipulation of noncoding RNAs, in particular microRNAs, was proved to promote or suppress CM proliferation, indicating that noncoding RNAs are involved in the underlying mechanism of CM proliferation. This review mainly summarizes the roles of noncoding RNAs, as a class of influential factors, in the regulation of CM proliferation.