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Stem Cells International
Volume 2018 (2018), Article ID 9432616, 13 pages
Research Article

Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells

1Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea
2Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea

Correspondence should be addressed to Ji Hyeon Ju

Received 28 July 2017; Revised 9 October 2017; Accepted 16 October 2017; Published 21 January 2018

Academic Editor: Celeste Scotti

Copyright © 2018 Yeri Alice Rim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs). Every somatic cell can theoretically become a hiPSC and give rise to targeted cells of the human body. However, there have been debates on the controversy about the differentiation propensity according to the origin of primary cells. We reprogrammed hiPSCs from four different types of primary cells such as dermal fibroblasts (DF, ), peripheral blood mononuclear cells (PBMC, ), cord blood mononuclear cells (CBMC, ), and osteoarthritis fibroblast-like synoviocytes (OAFLS, ). Established hiPSCs were differentiated into chondrogenic pellets. All told, cartilage-specific markers tended to express more by the order of CBMC > DF > PBMC > FLS. Origin of primary cells may influence the reprogramming and differentiation thereafter. In the context of chondrogenic propensity, CBMC-derived hiPSCs can be a fairly good candidate cell source for cartilage regeneration. The differentiation of hiPSCs into chondrocytes may help develop “cartilage in a dish” in the future. Also, the ideal cell source of hiPSC for chondrogenesis may contribute to future application as well.