Epigenetic Clock: DNA Methylation in Aging

Figure 1

Modulation of DNA methylation in mammals. (a) DNA 5mC methylated site is the fifth position of cytosine, while 6mA modification occurs at the sixth position of adenine in DNA. (b) Methylation marks are established by writers, such as DNMTs and N6AMT1. These modifications are identified by readers, like methyl-CpG-binding domain (MBD) proteins. Erasers, among which TETs and ALKBH1 are representatives, can make all the marks invalid by oxidizing or removing methyl groups.

(a)

(b)