Stem Cells International

The Current State of Cell Therapies for Cerebrovascular Diseases


Status
Published

1Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

2Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany

3University of Eastern Finland, Kuopio, Finland

4D'Or Institute of Research and Education, Rio de Janeiro, Brazil


The Current State of Cell Therapies for Cerebrovascular Diseases

Description

Even though cerebrovascular diseases are amongst the main causes of global health burden, currently available treatments have limited potential in the improvement of such conditions. Cell therapies, firstly employed in hematological ailments, are now being studied in detail as possible therapeutic approaches for different disorders. In the preclinical setting, numerous experimental studies have indicated that cell therapies may lead to positive functional and structural effects in cerebrovascular disease models, but the mechanisms for these therapies are the focus of continuous investigation. In the clinical field, there have only been initial reports until now, and further studies are necessary to evaluate the potential safety and efficacy of cell therapies in cerebrovascular patients. Moreover, the process of transferring results from experimental treatment studies to clinically applicable treatment procedures comes with a number of challenges we have to be aware of, including regulatory and technological ones.

In this special issue, we welcome submissions from researchers investigating animal models of cerebrovascular diseases, as well as those of from clinicians working with patients affected by focal and global cerebral ischemia, hemorrhagic stroke, and hypoxic-ischemic encephalopathy including vascular dementia. Special emphasis shall be given on the translational process and on aspects helping us to understand how we can enhance its safety, efficacy, speed, and patient orientation. Therefore, we invite the contribution of original research, review articles, and concept papers.

Potential topics include, but are not limited to:

  • Basic mechanisms and exploratory research
    • Mechanisms of cell therapies for cerebrovascular diseases
    • Evaluation of different cell types in potential therapies for cerebrovascular diseases
    • Combination therapies and neurorehabilitation
    • Regeneration versus compensation
  • Translational challenges and opportunities
    • Investigations on the timing and dosing of cell therapies for cerebrovascular diseases
    • Assessment of different administration routes and targeted cell delivery strategies
    • Challenges in GMP-grade cell production including appropriate potency assays
    • Behavioral testing in confirmative research
  • Clinical implementation and assessment
    • Next generation technologies for noninvasive cell tracking, safety, and efficacy readout
    • Identification of proper clinical outcome and efficacy measures and related statistics
    • Potential challenges related to comorbidities, age, and polypharmacology
    • Patient-centered, multidisciplinary treatment strategies, and precision medicine approaches

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5215824
  • - Editorial

The Current State of Cell Therapies for Cerebrovascular Diseases

Jukka Jolkkonen | Rosalia Mendez-Otero | ... | Paulo Henrique Rosado-de-Castro
  • Special Issue
  • - Volume 2016
  • - Article ID 4617983
  • - Review Article

Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage

Paulo Henrique Rosado-de-Castro | Felipe Gonçalves de Carvalho | ... | Pedro Moreno Pimentel-Coelho
  • Special Issue
  • - Volume 2016
  • - Article ID 2165462
  • - Research Article

Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells

Wen-Hui Fang | Shant Kumar | ... | Mark Slevin
  • Special Issue
  • - Volume 2016
  • - Article ID 8657173
  • - Research Article

Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials

Francisco Moniche | Paulo Henrique Rosado-de-Castro | ... | Joan Montaner
  • Special Issue
  • - Volume 2016
  • - Article ID 2715196
  • - Research Article

Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain

Anton Pikhovych | Nina Paloma Stolberg | ... | Maria Adele Rueger
  • Special Issue
  • - Volume 2016
  • - Article ID 5876836
  • - Research Article

Cryopreservation of Bone Marrow Mononuclear Cells Alters Their Viability and Subpopulation Composition but Not Their Treatment Effects in a Rodent Stroke Model

Bing Yang | Kaushik Parsha | ... | Sean I. Savitz
  • Special Issue
  • - Volume 2016
  • - Article ID 6810562
  • - Review Article

Biomaterial Applications in Cell-Based Therapy in Experimental Stroke

Ligia S. B. Boisserand | Tomonobu Kodama | ... | Olivier Detante
  • Special Issue
  • - Volume 2016
  • - Article ID 4956063
  • - Review Article

Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

Adam Nowakowski | Piotr Walczak | ... | Miroslaw Janowski
  • Special Issue
  • - Volume 2016
  • - Article ID 1764938
  • - Research Article

Clumping and Viability of Bone Marrow Derived Mesenchymal Stromal Cells under Different Preparation Procedures: A Flow Cytometry-Based In Vitro Study

Li-li Cui | Tuure Kinnunen | ... | Jukka Jolkkonen
Stem Cells International
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