Stem Cells International

Exogenous and Endogenous Stem Cells for Skeletal Regeneration


Status
Published

Lead Editor
Guest Editors

1Institute of Beijing Basic Medical Sciences, Beijing, China

2UCLA School of Dentistry, Los Angeles, USA

3Fourth Military Medical University, Xi’an, China


Exogenous and Endogenous Stem Cells for Skeletal Regeneration

Description

Stem cell-based therapies to promote skeletal regeneration have been the focus of intensive efforts in the past decades. While important progress has been made, substantial challenges remain in the field regarding the identity and function as well as the clinical translation of stem cells. The molecular and epigenetic control of stem cell states and dynamic interactions between stem cells and the tissue microenvironment have been fundamental questions, whose answers are underpinnings for efficient clinical applications. Therapeutically, several key approaches have emerged recently, including transplantation of in vitro cultured stem cells or reconstituted tissues, as well as homing and reprogramming of native stem cells. Although skeletal regeneration mediated by exogenous stem cells have been promising, the approach is confined by limitations including insufficient homing of stem cells to repair site, low efficiency of stem cell engraftment, and reduced differentiation of stem cells in vivo. To overcome these challenges, many strategies have been developed to enhance transplanted stem cell homing, engraftment, and differentiation. Alternatively, exciting strategies have been developed to target endogenous stem cells to reprogram their lineage commitment and improve their regeneration potentials.

To highlight the tremendous advances taking place in the field, this special issue aims to discuss new strategies for circumventing the hurdles in skeletal regeneration by exploiting exogenous and endogenous stem cells. Therefore, we welcome original research articles as well as review articles.

Potential topics include but are not limited to the following:

  • Identification and characterization of novel stem/progenitor cell populations in skeletal tissues
  • Molecular and epigenetic mechanisms governing skeletal stem cell self-renewal and differentiation
  • Dynamic interactions between stem/progenitor cells with tissue niche and microenvironment
  • Novel growth factors, small molecules, or antibodies targeting native/endogenous stem cells for treatment of skeletal disorders
  • Novel approaches to enhance cells homing of stem/progenitor cells to the injured site and promote skeleton regeneration
  • Novel biomaterial/scaffolds that enhance skeletal tissue repair and regeneration

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 2574243
  • - Editorial

Exogenous and Endogenous Stem Cells for Skeletal Regeneration

Heng Zhu | Bo Yu | Liu Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 3272098
  • - Research Article

The Effects of Platelet-Derived Growth Factor-BB on Bone Marrow Stromal Cell-Mediated Vascularized Bone Regeneration

Maolin Zhang | Wenwen Yu | ... | Xinquan Jiang
  • Special Issue
  • - Volume 2018
  • - Article ID 8478953
  • - Research Article

Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System

Shuaishuai Zhang | Junqin Li | ... | Guoxian Pei
  • Special Issue
  • - Volume 2018
  • - Article ID 6310560
  • - Research Article

EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization

Xiaoshi Jia | Hudi Xu | ... | Yufeng Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 5310471
  • - Review Article

Cell-Free Strategies for Repair and Regeneration of Meniscus Injuries through the Recruitment of Endogenous Stem/Progenitor Cells

Weimin Guo | Wenjing Xu | ... | Quanyi Guo
  • Special Issue
  • - Volume 2018
  • - Article ID 3712083
  • - Review Article

Deubiquitinating Enzymes and Bone Remodeling

Yu-chen Guo | Shi-wen Zhang | Quan Yuan
  • Special Issue
  • - Volume 2018
  • - Article ID 3057624
  • - Review Article

Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application

Mengyuan Wang | Quan Yuan | Liang Xie
  • Special Issue
  • - Volume 2018
  • - Article ID 7098456
  • - Review Article

Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration

Qiwen Li | Yunshu Wu | Ning Kang
  • Special Issue
  • - Volume 2018
  • - Article ID 7139485
  • - Research Article

Synergistic Effects of FGF-18 and TGF-β3 on the Chondrogenesis of Human Adipose-Derived Mesenchymal Stem Cells in the Pellet Culture

Liangjie Huang | Lingxian Yi | ... | Tujun Weng
  • Special Issue
  • - Volume 2018
  • - Article ID 7549160
  • - Review Article

The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal

Wen Du | Wei Du | Haiyang Yu
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision78 days
Acceptance to publication41 days
CiteScore3.800
Impact Factor3.902
 Submit