Stem Cells International

Stem Cell Differentiation and Therapeutic Use


Status
Published

1Boston Children's Hospital/Harvard Medical School, Boston, USA

2Pontificia Universidad Católica de Chile, Santiago, Chile

3Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan


Stem Cell Differentiation and Therapeutic Use

Description

With increased funding efforts by governments and private agencies to produce patient-ready stem cell therapies, the age of the stem cell in the clinic has clearly arrived. The awarding of the 2012 Nobel Prize in Physiology or Medicine to two stem cell biologists (Sir John Gurdon and Shinya Yamanaka) highlights the efforts of stem cell biologists to determine what factors define a stem cell from a somatic cell. Recently, the Japanese government announced a significant investment of funds to fast-track iPS-cell based therapies for clinical use in patients (http://www.nature.com/news/stem-cells-cruise-to-clinic-1.12511). Although one must emphasize caution for unproven stem cell “clinics” and treatments that are based on dubious science, there is a growing demand for both therapeutic application and understanding of what applications stem cells might be used for the amelioration and potentially curing of disease. The rise in the number of suspect stem cell clinics and therapies correlates with patient frustration over the speed at which new stem cell therapies are approved.

Additionally, newer whole genome/transcriptome technologies that have emerged over the past few years (RNA-seq, genome editing with TALENs or CRISPRs, etc.) made our understanding of how stem cells come to exist in the embryo and how they can be manipulated easier and more time-efficient. Whole signaling pathways involved in stem cell regulation can be quickly identified and manipulated in cell culture using various new screening platforms. With all of these new emerging technologies, an emphasis on their use to identify new compounds to correct disease, understand the mechanisms of disease, and form new tissues/organs must be made clear to the public to ensure their trust in well-vetted and scrutinized stem cell therapies.

In this special issue of Stem Cells International, we invite investigators to contribute original research articles and reviews on the topic of “Stem Cell Differentiation and Therapeutic Use.” We are especially seeking articles on the clinical use and/or application of stem cells for the treatment of human diseases.

Potential topics include, but are not limited to:

  • Differentiation of stem cells (adult, iPS, embryonic stem (ES), and germ cells) in somatic cells
  • Mechanisms underlying the maintenance of stem cell pluripotency
  • The screening of stem cells using small molecules or drug compounds
  • The use of nonrodent or human models of stem cells (e.g., zebrafish, axolotl, etc.)
  • Epigenetic regulation of stem cell differentiation and maintenance (microRNA, lncRNA, and histone/chromatin modifiers)
  • The aging of stem cells and factors that affect this process
  • Stem cell use in the regeneration of tissues/organs and specific human diseases

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 308128
  • - Editorial

Stem Cell Differentiation and Therapeutic Use

Matthew S. Alexander | Juan Carlos Casar | Norio Motohashi
  • Special Issue
  • - Volume 2015
  • - Article ID 162410
  • - Research Article

Acute Lymphoblastic Leukemia Cells Inhibit the Differentiation of Bone Mesenchymal Stem Cells into Osteoblasts In Vitro by Activating Notch Signaling

Gui-Cun Yang | You-Hua Xu | ... | Xiao-Jing Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 984146
  • - Research Article

Study of Bone Marrow Mesenchymal and Tendon-Derived Stem Cells Transplantation on the Regenerating Effect of Achilles Tendon Ruptures in Rats

Mohanad Kh Al-ani | Kang Xu | ... | Li Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 524756
  • - Review Article

Mesenchymal Stem Cells for Cardiac Regenerative Therapy: Optimization of Cell Differentiation Strategy

Han Shen | Ying Wang | ... | Zhenya Shen
  • Special Issue
  • - Volume 2015
  • - Article ID 328957
  • - Research Article

Rat Nasal Respiratory Mucosa-Derived Ectomesenchymal Stem Cells Differentiate into Schwann-Like Cells Promoting the Differentiation of PC12 Cells and Forming Myelin In Vitro

Jian Zhang | Xin Gao | ... | Zhijian Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 196348
  • - Research Article

Modifications of Human Subcutaneous ADMSC after PPARγ Activation and Cold Exposition

Diana Vargas | Wendy Rosales | Fernando Lizcano
  • Special Issue
  • - Volume 2015
  • - Article ID 931420
  • - Review Article

Cell Therapy in Patients with Critical Limb Ischemia

Rita Compagna | Bruno Amato | ... | Raffaele Serra
  • Special Issue
  • - Volume 2015
  • - Article ID 412467
  • - Research Article

Analysis of the Pro- and Anti-Inflammatory Cytokines Secreted by Adult Stem Cells during Differentiation

Amy L. Strong | Jeffrey M. Gimble | Bruce A. Bunnell
  • Special Issue
  • - Volume 2015
  • - Article ID 960387
  • - Research Article

SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

Ning-Bo Hao | Chang-Zhu Li | ... | Shi-Ming Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 734731
  • - Review Article

Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century

J.-F. Stoltz | N. de Isla | ... | Y. He
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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