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Stroke Research and Treatment
Volume 2011 (2011), Article ID 920584, 5 pages
Research Article

Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population

1Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, Greece
2Laboratory of Medical Genetics, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, Greece
3Neurosurgical Research Institute, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
4Department of Clinical Therapeutics, National and Kapodistrian, University of Athens, 11528 Athens, Greece

Received 17 November 2010; Revised 12 February 2011; Accepted 15 March 2011

Academic Editor: Stefan Engelter

Copyright © 2011 Sofia Markoula et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated. Results. TNFα-857TT, TNFR136AA, and TNFR2676TT genotypes were significantly increased in the patient group compared to controls ( 𝑃 = . 0 0 8 , OR = 2.47 (1.26–4.84), 𝑃 = . 0 0 5 , OR = 1.97 (1.22–3.17), and 𝑃 = . 0 0 3 , OR = 2.2 (1.43–3.37), resp.). In addition, the TNFR136A and the TNFR2676T alleles were found significantly increased in patients compared to controls ( 𝑃 = . 0 0 9 , OR = 1.48 (1.1–2) and 𝑃 = . 0 0 1 , OR = 1.75 (1.25–2.46), resp.). Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility.