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Karoly Mirnics, Frank A. Middleton, David A. Lewis, Pat Levitt, "Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays", The Scientific World Journal, vol. 1, Article ID 504748, 3 pages, 2001. https://doi.org/10.1100/tsw.2001.17
Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays
Schizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucinations (positive symptoms); decreased motivation, emotional expression, and social interactions (negative symptoms); and impaired learning and memory (cognitive symptoms). The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia.