The Scientific World Journal

The Scientific World Journal / 2001 / Article
Special Issue

Collection of Directions in Science Articles from TheScientificWorldJOURNAL

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Directions in Science | Open Access

Volume 1 |Article ID 504748 | 3 pages |

Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays


Schizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucinations (positive symptoms); decreased motivation, emotional expression, and social interactions (negative symptoms); and impaired learning and memory (cognitive symptoms). The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia.

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