Table of Contents Author Guidelines Submit a Manuscript
TheScientificWorldJOURNAL
Volume 1, Pages 114-116
http://dx.doi.org/10.1100/tsw.2001.17
Directions in Science

Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays

Department of neurobiology, University of Pittsburgh School of Medicine, PA 15261, USA

Copyright © 2001 Karoly Mirnics et al.

Abstract

Schizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucinations (positive symptoms); decreased motivation, emotional expression, and social interactions (negative symptoms); and impaired learning and memory (cognitive symptoms). The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia.