Research Article
Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
Table 1
Dependent variables in the first set of experiments.
| | Factor (variable) | Symbol | Low level (ā1) | High level (+1) |
| | Type of diluent | X1 | Anhydrous lactose | Microcrystalline cellulose | | Concentration PEO1 | X2 | 5 | 10 | | Temperature during mixing and granulation () | X3 | 55 | 65 | | Air flow rate during mixing (m3/h) | X4 | 20 | 30 | | Air flow rate during drying (m3/h) | X5 | 20 | 30 | | Spray rate (g/min) | X6 | 5 | 10 | | Atomization pressure (bar) | X7 | Spray air 0.5 | Spray air 1.0 | | Microclimate 0.25 | Microclimate 0.5 |
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1PEO: polyethylene-oxide.
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