Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process

Table 5

Granules characterization.

		Y1			Y2	Y3	Y4	Y5	Y6	Y7
	𝑑 < 180	180 < 𝑑 < 315	315 < 𝑑 < 500	𝑑 > 500
1	52.82	39.75	7.38	0.05	7.28 ± 0.6	0.625	0.750	1.20	16.67	1.4
2	97.84	1.86	0.30	0.00	2.90 ± 0.2	0.385	0.517	1.34	25.53	3.9
3	74.31	10.28	6.44	8.97	0.00	0.341	0.468	1.37	27.14	10.1
4	52.73	39.57	7.64	0.06	7.54 ± 0.5	0.600	0.750	1.25	20.00	0.9
5	97.38	2.22	0.40	0.00	2.50 ± 0.2	0.366	0.517	1.41	29.21	3.2
6	35.14	47.97	16.64	0.25	6.02 ± 0.4	0.555	0.682	1.23	18.62	1.0
7	17.72	48.04	33.47	0.78	6.55 ± 0.4	0.469	0.600	1.28	21.83	3.0
8	93.39	5.79	0.83	0.00	2.83 ± 0.2	0.395	0.536	1.36	26.31	3.2

Y1: granules size distribution (%).
Y2: flowability (g/s).
Y3: bulk density (g/mL).
Y4: tapped density (g/mL).
Y5: Hausner’s ratio.
Y6: Carr’s index (%).
Y7: moisture content (%).