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The Scientific World Journal
Volume 2012, Article ID 647403, 7 pages
Review Article

Histopathological Analogies in Chronic Pulmonary Lesions between Cattle and Humans: Basis for an Alternative Animal Model

Pathobiology Group, Faculty of Veterinary Medicine, Autonomous University of Nuevo León (UANL), Avenida Universidad S/N Ciudad Universitaria, 66451 San Nicolas de los Garza, NL, Mexico

Received 11 October 2011; Accepted 8 December 2011

Academic Editors: T. Goldmann and N. Miyahara

Copyright © 2012 Rafael Ramírez-Romero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model.