Review Article
Renin and the IGFII/M6P Receptor System in Cardiac Biology
Table 1
Selected examples of the effect of pharmacological intervention at various sites of the RAAS on plasma renin concentration.
| Species | Site of inhibition | Renin concentration | References | Basal | Treatment |
| Human | Renin (aliskiren) | 14.9 mU/L | 48.4 mU/L | [5] | Human | ACE (ramipril) | 14.4 mU/L | 35.2 mU/L | [5] | Human | AT1 (irbesartan) | 17 mU/L | 56 mU/L | [6] | Human | Renin (aliskiren) | 5.6 pg/mL | 34.9 pg/mL* | [7] | Human | AT1 (irbesartan) | 5.6 pg/mL | 11.3 pg/mL | [7] | Rat (SHR) | Renin (aliskiren) | mg/kg | mg/kg | [8] | Rat (SHR) | ACE (captopril) | mg/kg | mg/kg* | [8] | Rat (SHR) | ACE (captopril) | ng/mL | ng/mL* | [9] | Rat (SHR) | AT1 (irbesartan) | mg/kg | mg/kg* | [8] | Mouse (ApoE−/−) | Renin (aliskiren) | ng/mL | mg/mL | [10] | Mouse (ApoE−/−) | AT1 (irbesartan) | 755 ng/mL | ng/mL | [10] |
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