The Scientific World Journal / 2013 / Article / Tab 1

Review Article

Renin and the IGFII/M6P Receptor System in Cardiac Biology

Table 1

Selected examples of the effect of pharmacological intervention at various sites of the RAAS on plasma renin concentration.

SpeciesSite of inhibitionRenin concentrationReferences
BasalTreatment

HumanRenin (aliskiren)14.9 mU/L48.4 mU/L[5]
HumanACE (ramipril)14.4 mU/L35.2 mU/L[5]
HumanAT1 (irbesartan)17 mU/L56 mU/L[6]
HumanRenin (aliskiren)5.6 pg/mL34.9 pg/mL*[7]
HumanAT1 (irbesartan)5.6 pg/mL11.3 pg/mL[7]
Rat (SHR)Renin (aliskiren)  mg/kg  mg/kg[8]
Rat (SHR)ACE (captopril)  mg/kg  mg/kg*[8]
Rat (SHR)ACE (captopril)  ng/mL  ng/mL*[9]
Rat (SHR)AT1 (irbesartan)  mg/kg  mg/kg*[8]
Mouse (ApoE−/−)Renin (aliskiren)  ng/mL  mg/mL[10]
Mouse (ApoE−/−)AT1 (irbesartan)755 ng/mL  ng/mL[10]

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