Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol

Figure 3

Effects of N-acetylcysteine (NAC) and/or iron (Fe) short-term administration on rat liver histology in animals subjected to ischemia-reperfusion (IR). Animals were treated as shown in Figure 1. Representative liver sections from control-sham (a), control-IR (b), Fe-sham (c), and Fe-IR (d) animals, and NAC-treated rats subjected to sham operation (e), IR (f), Fe-pretreatment and sham-operation (g), Fe pretreatment and IR (h) (hematoxylin-eosin-stained liver sections from a total of 3 to 4 animals per experimental group; original magnification ×20).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)