Local Gene Transfer of OPG Prevents Joint Damage and Disease Progression in Collagen-Induced Arthritis
Figure 3
(a)–(c) Typical histological appearance of CIA mouse paws: (a) severe inflammatory cellular infiltration—synovitis and pannus formation; (b) bone and cartilage erosion; (c) toluidine blue stained section showing destruction of articular cartilage with loss of joint space and complete architecture distortion. Panels (d)–(f), example histological images of mouse paws after OPG gene modification: joint space was maintained and dramatically less bone and cartilage damage were obvious. (f) A Toluidine Blue stained paw section showing the protection effect on articulating cartilage.
