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The Scientific World Journal
Volume 2014 (2014), Article ID 130381, 10 pages
http://dx.doi.org/10.1155/2014/130381
Research Article

Andrographolide Inhibits Nuclear Factor-B Activation through JNK-Akt-p65 Signaling Cascade in Tumor Necrosis Factor-α-Stimulated Vascular Smooth Muscle Cells

1Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
2Department of Pharmacology, School of Medicine, Taipei Medical University, Taipei 11031, Taiwan
3Department of Microbiology and Immunology, Taipei Medical University, Taipei 11031, Taiwan
4Department of Cardiology, Chi-Mei Medical Center, Tainan City 71004, Taiwan
5Department of Pharmacy, Chia Nan University of Pharmacy & Science, Tainan City 71004, Taiwan

Received 27 May 2014; Accepted 30 June 2014; Published 10 July 2014

Academic Editor: Duen-Suey Chou

Copyright © 2014 Yu-Ying Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Phitchayapak Wintachai, Duncan R. Smith, Parveen Kaur, Regina Ching Hua Lee, Suwipa Ramphan, Atichat Kuadkitkan, Nitwara Wikan, Sukathida Ubol, Sittiruk Roytrakul, and Justin Jang Hann Chu, “Activity of andrographolide against chikungunya virus infection,” Scientific Reports, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Siew Ying Wong, Michelle G.K. Tan, William A. Banks, W.S.Fred Wong, Peter T.-H. Wong, and Mitchell K.P. Lai, “Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes,” Journal of Neuroinflammation, vol. 13, no. 1, 2016. View at Publisher · View at Google Scholar
  • Cuiqing Liu, and Yu Huang, “Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action,” Frontiers in Pharmacology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Swati Gupta, K. P. Mishra, and Lilly Ganju, “Broad-spectrum antiviral properties of andrographolide,” Archives of Virology, 2016. View at Publisher · View at Google Scholar
  • Sha Liu, Jia Zhou, Jian Zhang, Rui Yang, and Shuhong Bu, “Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway,” Immunopharmacology and Immunotoxicology, vol. 39, no. 5, pp. 276–284, 2017. View at Publisher · View at Google Scholar
  • Muhammad T. Islam, “Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Chih-Hao Yang, Ting-Lin Yen, Chia-Yuan Hsu, Philip-Aloysius Thomas, Joen-Rong Sheu, and Thanasekaran Jayakumar, “Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke,” International Journal of Molecular Sciences, vol. 18, no. 8, pp. 1638, 2017. View at Publisher · View at Google Scholar