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The Scientific World Journal
Volume 2014, Article ID 567148, 11 pages
http://dx.doi.org/10.1155/2014/567148
Research Article

Progesterone Increases Apoptosis and Inversely Decreases Autophagy in Human Hepatoma HA22T/VGH Cells Treated with Epirubicin

1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
3Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4Department of Biochemistry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
5Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Received 20 March 2014; Accepted 1 May 2014; Published 19 May 2014

Academic Editor: Hsueh-Wei Chang

Copyright © 2014 Wen-Tsan Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Wen-Lei Zhuo, Liang Zhang, Qi-Chao Xie, Bo Zhu, and Zheng-Tang Chen, “Identifying Differentially Expressed Genes and Screening Small Molecule Drugs for Lapatinib-resistance of Breast Cancer by a Bioinformatics Strategy,” Asian Pacific Journal Of Cancer Prevention, vol. 15, no. 24, pp. 10847–10853, 2014. View at Publisher · View at Google Scholar
  • Prashanta Kumar Panda, Subhadip Mukhopadhyay, Durgesh Nandini Das, Niharika Sinha, Prajna Paramita Naik, and Sujit K. Bhutia, “Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics,” Seminars in Cell & Developmental Biology, 2015. View at Publisher · View at Google Scholar
  • Nan Zhang, Yaran Wu, Xilin Lyu, Bo Li, Xiaojing Yan, Haojun Xiong, Xinzhe Li, Gang Huang, Yijun Zeng, Yan Zhang, Jiqin Lian, Zhenhong Ni, and Fengtian He, “HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells,” Cancer Letters, 2017. View at Publisher · View at Google Scholar
  • Wen-Tsan Chang, Wangta Liu, Yi-Han Chiu, Bing-Hung Chen, Shih-Chang Chuang, Yen-Chun Chen, Yun-Tzh Hsu, Mei-Jei Lu, Shean-Jaw Chiou, Chon-Kit Chou, and Chien-Chih Chiu, “A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression,” Molecules, vol. 22, no. 6, pp. 854, 2017. View at Publisher · View at Google Scholar
  • Gu, Lin, Gou, and He, “Tea polyphenol inhibits autophagy to sensitize epirubicin-induced apoptosis in human bladder cancer cells,” Neoplasma, vol. 64, no. 5, pp. 674–680, 2017. View at Publisher · View at Google Scholar
  • Hung-Wen Tsai, Chung-Liang Ho, Shu-Wen Cheng, Yih-Jyh Lin, Chou-Cheng Chen, Pin-Nan Cheng, Chia-Jui Yen, Ting-Tsung Chang, Po-Min Chiang, Shih-Huang Chan, Cheng-Hsun Ho, Shu-Hui Chen, Yi-Wen Wang, Nan-Haw Chow, and Jou-Chun Lin, “Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 24, no. 10, pp. 1152–1166, 2018. View at Publisher · View at Google Scholar
  • Tzu-Ching Huang, Pu-Rong Chiu, Wen-Tsan Chang, Bau-Shan Hsieh, Yu-Ci Huang, Hsiao-Ling Cheng, Li-Wen Huang, Yu-Chen Hu, and Kee-Lung Chang, “Epirubicin induces apoptosis in osteoblasts through death-receptor and mitochondrial pathways,” Apoptosis, 2018. View at Publisher · View at Google Scholar