The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis
Figure 2
Sirtinol inhibits the colony formation of lung cancer cells. H1299 cells were treated with different concentrations (5, 10, 20 and 50 μM) of sirtinol for 15 days, respectively. Afterwards, the cells were glutaraldehyde-fixed and stained with Giemsa stain for 1 h. (a) The colony formation analysis of H1299 cells. (b) The quantification analysis of the colony diameter. Data are represented as mean ± SD (). compared with the vehicle control.
